Matches in SemOpenAlex for { <https://semopenalex.org/work/W1631661663> ?p ?o ?g. }
- W1631661663 endingPage "4334" @default.
- W1631661663 startingPage "4323" @default.
- W1631661663 abstract "Tumor growth is allowed by its ability to escape immune system surveillance. An important role in determining tumor evasion from immune control might be played by tumor-infiltrating regulatory lymphocytes. This study was aimed at characterizing phenotype and function of CD8+ CD28- T regulatory cells infiltrating human cancer. Lymphocytes infiltrating primitive tumor lesion and/or satellite lymph node from a series of 42 human cancers were phenotypically studied and functionally analyzed by suppressor assays. The unprecedented observation was made that CD8+ CD28- T regulatory lymphocytes are almost constantly present and functional in human tumors, being able to inhibit both T cell proliferation and cytotoxicity. CD4+ CD25+ T regulatory lymphocytes associate with CD8+ CD28- T regulatory cells so that the immunosuppressive activity of tumor-infiltrating regulatory T cell subsets, altogether considered, may become predominant. The infiltration of regulatory T cells seems tumor related, being present in metastatic but not in metastasis-free satellite lymph nodes; it likely depends on both in situ generation (via cytokine production) and recruitment from the periphery (via chemokine secretion). Collectively, these results have pathogenic relevance and implication for immunotherapy of cancer." @default.
- W1631661663 created "2016-06-24" @default.
- W1631661663 creator A5005025196 @default.
- W1631661663 creator A5006348451 @default.
- W1631661663 creator A5016739655 @default.
- W1631661663 creator A5017162886 @default.
- W1631661663 creator A5018411391 @default.
- W1631661663 creator A5021752739 @default.
- W1631661663 creator A5022209679 @default.
- W1631661663 creator A5029679351 @default.
- W1631661663 creator A5039482178 @default.
- W1631661663 creator A5039803007 @default.
- W1631661663 creator A5047357164 @default.
- W1631661663 creator A5049096801 @default.
- W1631661663 creator A5051131490 @default.
- W1631661663 creator A5053647623 @default.
- W1631661663 creator A5054329673 @default.
- W1631661663 creator A5057237295 @default.
- W1631661663 creator A5057355052 @default.
- W1631661663 creator A5059849328 @default.
- W1631661663 creator A5063459245 @default.
- W1631661663 creator A5067130827 @default.
- W1631661663 creator A5072890495 @default.
- W1631661663 date "2007-10-01" @default.
- W1631661663 modified "2023-10-14" @default.
- W1631661663 title "CD8+CD28− T Regulatory Lymphocytes Inhibiting T Cell Proliferative and Cytotoxic Functions Infiltrate Human Cancers" @default.
- W1631661663 cites W1526518539 @default.
- W1631661663 cites W1537666383 @default.
- W1631661663 cites W1627814885 @default.
- W1631661663 cites W1981480494 @default.
- W1631661663 cites W1988181926 @default.
- W1631661663 cites W1992411581 @default.
- W1631661663 cites W2002233516 @default.
- W1631661663 cites W2012107785 @default.
- W1631661663 cites W2022022565 @default.
- W1631661663 cites W2029855686 @default.
- W1631661663 cites W2051034601 @default.
- W1631661663 cites W2051782273 @default.
- W1631661663 cites W2058777847 @default.
- W1631661663 cites W2067873282 @default.
- W1631661663 cites W2073310925 @default.
- W1631661663 cites W2077246243 @default.
- W1631661663 cites W2078249603 @default.
- W1631661663 cites W2081379792 @default.
- W1631661663 cites W2091813424 @default.
- W1631661663 cites W2094254406 @default.
- W1631661663 cites W2096151993 @default.
- W1631661663 cites W2096554723 @default.
- W1631661663 cites W2104401164 @default.
- W1631661663 cites W2105459360 @default.
- W1631661663 cites W2108782816 @default.
- W1631661663 cites W2108860192 @default.
- W1631661663 cites W2151237411 @default.
- W1631661663 cites W2154203858 @default.
- W1631661663 cites W2157276434 @default.
- W1631661663 cites W2158164086 @default.
- W1631661663 cites W2166798619 @default.
- W1631661663 cites W2170095111 @default.
- W1631661663 doi "https://doi.org/10.4049/jimmunol.179.7.4323" @default.
- W1631661663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17878327" @default.
- W1631661663 hasPublicationYear "2007" @default.
- W1631661663 type Work @default.
- W1631661663 sameAs 1631661663 @default.
- W1631661663 citedByCount "207" @default.
- W1631661663 countsByYear W16316616632012 @default.
- W1631661663 countsByYear W16316616632013 @default.
- W1631661663 countsByYear W16316616632014 @default.
- W1631661663 countsByYear W16316616632015 @default.
- W1631661663 countsByYear W16316616632016 @default.
- W1631661663 countsByYear W16316616632017 @default.
- W1631661663 countsByYear W16316616632018 @default.
- W1631661663 countsByYear W16316616632019 @default.
- W1631661663 countsByYear W16316616632020 @default.
- W1631661663 countsByYear W16316616632021 @default.
- W1631661663 countsByYear W16316616632022 @default.
- W1631661663 countsByYear W16316616632023 @default.
- W1631661663 crossrefType "journal-article" @default.
- W1631661663 hasAuthorship W1631661663A5005025196 @default.
- W1631661663 hasAuthorship W1631661663A5006348451 @default.
- W1631661663 hasAuthorship W1631661663A5016739655 @default.
- W1631661663 hasAuthorship W1631661663A5017162886 @default.
- W1631661663 hasAuthorship W1631661663A5018411391 @default.
- W1631661663 hasAuthorship W1631661663A5021752739 @default.
- W1631661663 hasAuthorship W1631661663A5022209679 @default.
- W1631661663 hasAuthorship W1631661663A5029679351 @default.
- W1631661663 hasAuthorship W1631661663A5039482178 @default.
- W1631661663 hasAuthorship W1631661663A5039803007 @default.
- W1631661663 hasAuthorship W1631661663A5047357164 @default.
- W1631661663 hasAuthorship W1631661663A5049096801 @default.
- W1631661663 hasAuthorship W1631661663A5051131490 @default.
- W1631661663 hasAuthorship W1631661663A5053647623 @default.
- W1631661663 hasAuthorship W1631661663A5054329673 @default.
- W1631661663 hasAuthorship W1631661663A5057237295 @default.
- W1631661663 hasAuthorship W1631661663A5057355052 @default.
- W1631661663 hasAuthorship W1631661663A5059849328 @default.
- W1631661663 hasAuthorship W1631661663A5063459245 @default.
- W1631661663 hasAuthorship W1631661663A5067130827 @default.
- W1631661663 hasAuthorship W1631661663A5072890495 @default.