Matches in SemOpenAlex for { <https://semopenalex.org/work/W163202073> ?p ?o ?g. }
- W163202073 abstract "Mesenchymal stem cells (MSCs) can serve as a vehicle for gene therapy. Angiopoietin-1 (ANGPT1) plays an important role in the regulation of endothelial cell survival, vascular stabilization, and angiogenesis. We hypothesized that ANGPT1 gene-modified MSCs might be a potential therapeutic approach for severe acute pancreatitis (SAP) in rats. Human umbilical cord-derived MSCs with or without transfection with lentiviral vectors containing the ANGPT1 gene were delivered through the tail vein of rats 12 h after induction of SAP. Administration of MSCs alone significantly reduced pancreatic injury and inflammation, as reflected by reductions in pancreatitis severity scores and serum amylase and lipase levels as well as reducing the serum levels of proinflammatory cytokines (TNF-α, IFN-γ, IL-1β, and IL-6). Furthermore, administration of ANGPT1-transfected MSCs resulted in not only further reductions in pancreatic injury and serum levels of proinflammatory cytokines, but also promotion of pancreatic angiogenesis. These results suggest that MSCs and ANGPT1 have a synergistic role in the treatment of SAP. ANGPT1 gene-modified MSCs may be developed as a potential novel therapy strategy for the treatment of SAP." @default.
- W163202073 created "2016-06-24" @default.
- W163202073 creator A5011488693 @default.
- W163202073 creator A5015479011 @default.
- W163202073 creator A5018171658 @default.
- W163202073 creator A5035121335 @default.
- W163202073 creator A5046606410 @default.
- W163202073 creator A5050529792 @default.
- W163202073 creator A5063913041 @default.
- W163202073 creator A5066687472 @default.
- W163202073 creator A5071884187 @default.
- W163202073 creator A5074243377 @default.
- W163202073 creator A5082610149 @default.
- W163202073 date "2014-01-01" @default.
- W163202073 modified "2023-10-05" @default.
- W163202073 title "Angiopoietin-1 gene-modified human mesenchymal stem cells promote angiogenesis and reduce acute pancreatitis in rats." @default.
- W163202073 cites W1484419249 @default.
- W163202073 cites W1601356379 @default.
- W163202073 cites W1975477951 @default.
- W163202073 cites W1976241882 @default.
- W163202073 cites W1979143620 @default.
- W163202073 cites W1979228443 @default.
- W163202073 cites W1985850927 @default.
- W163202073 cites W1994788053 @default.
- W163202073 cites W2002868143 @default.
- W163202073 cites W2003030880 @default.
- W163202073 cites W2003566728 @default.
- W163202073 cites W2018258390 @default.
- W163202073 cites W2021916724 @default.
- W163202073 cites W2022580158 @default.
- W163202073 cites W2024326908 @default.
- W163202073 cites W2025715974 @default.
- W163202073 cites W2027052612 @default.
- W163202073 cites W2031888856 @default.
- W163202073 cites W2051297632 @default.
- W163202073 cites W2054228133 @default.
- W163202073 cites W2057143670 @default.
- W163202073 cites W2067747048 @default.
- W163202073 cites W2070254401 @default.
- W163202073 cites W2075708296 @default.
- W163202073 cites W2077940360 @default.
- W163202073 cites W2081245927 @default.
- W163202073 cites W2082958780 @default.
- W163202073 cites W2082996896 @default.
- W163202073 cites W2085030928 @default.
- W163202073 cites W2089567126 @default.
- W163202073 cites W2095666785 @default.
- W163202073 cites W2105318783 @default.
- W163202073 cites W2113358240 @default.
- W163202073 cites W2133375451 @default.
- W163202073 cites W2136635426 @default.
- W163202073 cites W2156563204 @default.
- W163202073 cites W2157087666 @default.
- W163202073 cites W2169231236 @default.
- W163202073 cites W2312984445 @default.
- W163202073 cites W2981029611 @default.
- W163202073 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4128971" @default.
- W163202073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25120736" @default.
- W163202073 hasPublicationYear "2014" @default.
- W163202073 type Work @default.
- W163202073 sameAs 163202073 @default.
- W163202073 citedByCount "19" @default.
- W163202073 countsByYear W1632020732015 @default.
- W163202073 countsByYear W1632020732016 @default.
- W163202073 countsByYear W1632020732017 @default.
- W163202073 countsByYear W1632020732018 @default.
- W163202073 countsByYear W1632020732019 @default.
- W163202073 countsByYear W1632020732020 @default.
- W163202073 countsByYear W1632020732022 @default.
- W163202073 countsByYear W1632020732023 @default.
- W163202073 crossrefType "journal-article" @default.
- W163202073 hasAuthorship W163202073A5011488693 @default.
- W163202073 hasAuthorship W163202073A5015479011 @default.
- W163202073 hasAuthorship W163202073A5018171658 @default.
- W163202073 hasAuthorship W163202073A5035121335 @default.
- W163202073 hasAuthorship W163202073A5046606410 @default.
- W163202073 hasAuthorship W163202073A5050529792 @default.
- W163202073 hasAuthorship W163202073A5063913041 @default.
- W163202073 hasAuthorship W163202073A5066687472 @default.
- W163202073 hasAuthorship W163202073A5071884187 @default.
- W163202073 hasAuthorship W163202073A5074243377 @default.
- W163202073 hasAuthorship W163202073A5082610149 @default.
- W163202073 hasConcept C104317684 @default.
- W163202073 hasConcept C111599444 @default.
- W163202073 hasConcept C126322002 @default.
- W163202073 hasConcept C164027704 @default.
- W163202073 hasConcept C198826908 @default.
- W163202073 hasConcept C203014093 @default.
- W163202073 hasConcept C2776670229 @default.
- W163202073 hasConcept C2776914184 @default.
- W163202073 hasConcept C2780394083 @default.
- W163202073 hasConcept C28328180 @default.
- W163202073 hasConcept C502942594 @default.
- W163202073 hasConcept C55493867 @default.
- W163202073 hasConcept C71924100 @default.
- W163202073 hasConcept C86803240 @default.
- W163202073 hasConcept C95444343 @default.
- W163202073 hasConceptScore W163202073C104317684 @default.
- W163202073 hasConceptScore W163202073C111599444 @default.
- W163202073 hasConceptScore W163202073C126322002 @default.