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- W163208771 abstract "The ability to introduce foreign genes into an animal’s genome or to modify or delete existing genes provides a powerful means to study their impact in an intact organism. This technology has been extensively exploited to study the pathogenesis of Alzheimer’s disease (AD), a progressive neurodegenerative disease characterized by memory loss and cognitive decline. At the neuropathological level, the AD brain is marked by three principle features: (1) diffuse and neuritic plaques composed primarily of the β-amyloid (Aβ) peptide, (2) intracellular neurofibrillary tangles (NFTs), which consist of hyperphosphorylated tau protein, and (3) neuronal and synaptic loss (1). Thus, to faithfully model AD, an animal model must contain these three principle neuropathological features and the accompanying deficits in memory and cognition. To date, none of the existing models truly fulfills these criteria. Nevertheless, this should not imply that these existing models do not have value, because replicating one or more aspects of the disease provides a valuable experimental system to investigate the underlying pathogenic mechanisms and to evaluate potential therapeutic interventions." @default.
- W163208771 created "2016-06-24" @default.
- W163208771 creator A5026487650 @default.
- W163208771 creator A5033852499 @default.
- W163208771 creator A5047913548 @default.
- W163208771 date "2001-01-01" @default.
- W163208771 modified "2023-09-23" @default.
- W163208771 title "Transgenic Models of Alzheimer’s Disease" @default.
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