Matches in SemOpenAlex for { <https://semopenalex.org/work/W163348516> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W163348516 endingPage "7" @default.
- W163348516 startingPage "3" @default.
- W163348516 abstract "The remarkable insights into the pathogenesis of osteo-arthrosis (OA) have also affected the therapeutic field. Efforts have been made to find drugs which would somehow block or slow down the evolution of this disease. In this connection, a major contribution has been made by the investigations on glycosaminoglycans (GAGs), which play a crucial role in the physiology of joint cartilage. It was thus suggested that proper supplementation with GAGs might enable chondrocytes to replace the proteoglycans (PG). Galactosaminoglucuronoglycan sulfate (GAGGS) has been used for this purpose. In preliminary clinical trials, GAGGS exhibited a remarkable tolerability and good therapeutic efficacy. GAGs are generally able to inhibit certain enzymes present in the synovial fluid which may damage joint cartilage (elastase, hyaluronidase). Moreover, GAGGS has also been shown to act as an anti-inflammatory drug since it has an inhibitory effect over the complement. All these data supply evidence that, in theory, GAGGS may have a chondroprotective effect in patients with OA. In addition to the positive results of preliminary clinical trials, the use of GAGGS in OA therapy is based on the fact that this drug is absorbed by the body, is concentrated in the cartilages and produces no toxic or teratogenic effects. In the clinical studies performed so far, although of the open type, GAGGS has always yielded clinical improvement both of painful symptoms and of limited function thanks to its proven anti-inflammatory activity. Thus once the results from other ongoing trials (double blind) are available, hopefully GAGGS will in fact become a basic drug for OA therapy." @default.
- W163348516 created "2016-06-24" @default.
- W163348516 creator A5068140146 @default.
- W163348516 date "1991-01-01" @default.
- W163348516 modified "2023-09-22" @default.
- W163348516 title "Chondroprotection with chondroitin sulfate." @default.
- W163348516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1914834" @default.
- W163348516 hasPublicationYear "1991" @default.
- W163348516 type Work @default.
- W163348516 sameAs 163348516 @default.
- W163348516 citedByCount "15" @default.
- W163348516 countsByYear W1633485162013 @default.
- W163348516 countsByYear W1633485162014 @default.
- W163348516 countsByYear W1633485162015 @default.
- W163348516 countsByYear W1633485162016 @default.
- W163348516 crossrefType "journal-article" @default.
- W163348516 hasAuthorship W163348516A5068140146 @default.
- W163348516 hasConcept C105702510 @default.
- W163348516 hasConcept C126322002 @default.
- W163348516 hasConcept C142724271 @default.
- W163348516 hasConcept C153074725 @default.
- W163348516 hasConcept C197934379 @default.
- W163348516 hasConcept C204787440 @default.
- W163348516 hasConcept C2776164576 @default.
- W163348516 hasConcept C2776268809 @default.
- W163348516 hasConcept C2777529286 @default.
- W163348516 hasConcept C2778375690 @default.
- W163348516 hasConcept C2779553658 @default.
- W163348516 hasConcept C2780035454 @default.
- W163348516 hasConcept C2780550940 @default.
- W163348516 hasConcept C535046627 @default.
- W163348516 hasConcept C60644358 @default.
- W163348516 hasConcept C71924100 @default.
- W163348516 hasConcept C86803240 @default.
- W163348516 hasConcept C98274493 @default.
- W163348516 hasConceptScore W163348516C105702510 @default.
- W163348516 hasConceptScore W163348516C126322002 @default.
- W163348516 hasConceptScore W163348516C142724271 @default.
- W163348516 hasConceptScore W163348516C153074725 @default.
- W163348516 hasConceptScore W163348516C197934379 @default.
- W163348516 hasConceptScore W163348516C204787440 @default.
- W163348516 hasConceptScore W163348516C2776164576 @default.
- W163348516 hasConceptScore W163348516C2776268809 @default.
- W163348516 hasConceptScore W163348516C2777529286 @default.
- W163348516 hasConceptScore W163348516C2778375690 @default.
- W163348516 hasConceptScore W163348516C2779553658 @default.
- W163348516 hasConceptScore W163348516C2780035454 @default.
- W163348516 hasConceptScore W163348516C2780550940 @default.
- W163348516 hasConceptScore W163348516C535046627 @default.
- W163348516 hasConceptScore W163348516C60644358 @default.
- W163348516 hasConceptScore W163348516C71924100 @default.
- W163348516 hasConceptScore W163348516C86803240 @default.
- W163348516 hasConceptScore W163348516C98274493 @default.
- W163348516 hasIssue "1" @default.
- W163348516 hasLocation W1633485161 @default.
- W163348516 hasOpenAccess W163348516 @default.
- W163348516 hasPrimaryLocation W1633485161 @default.
- W163348516 hasRelatedWork W156986455 @default.
- W163348516 hasRelatedWork W1570732 @default.
- W163348516 hasRelatedWork W1729962335 @default.
- W163348516 hasRelatedWork W181253912 @default.
- W163348516 hasRelatedWork W191901781 @default.
- W163348516 hasRelatedWork W1977207093 @default.
- W163348516 hasRelatedWork W1984401291 @default.
- W163348516 hasRelatedWork W2009622554 @default.
- W163348516 hasRelatedWork W2016826188 @default.
- W163348516 hasRelatedWork W2019989482 @default.
- W163348516 hasRelatedWork W2065556610 @default.
- W163348516 hasRelatedWork W2080080639 @default.
- W163348516 hasRelatedWork W2083666488 @default.
- W163348516 hasRelatedWork W2124790232 @default.
- W163348516 hasRelatedWork W2148245038 @default.
- W163348516 hasRelatedWork W2283766515 @default.
- W163348516 hasRelatedWork W2285253591 @default.
- W163348516 hasRelatedWork W49380918 @default.
- W163348516 hasRelatedWork W65742195 @default.
- W163348516 hasRelatedWork W122338869 @default.
- W163348516 hasVolume "17" @default.
- W163348516 isParatext "false" @default.
- W163348516 isRetracted "false" @default.
- W163348516 magId "163348516" @default.
- W163348516 workType "article" @default.