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• W1633543075 abstract "Significant advances have been made in the field of transplantation since the first successful kidney transplant between identical twins in 1954. A better understanding of immunobiology and immunosuppression not only resulted in transplantation between genetically nonidentical individuals, but has led to declining rates of acute allograft rejection and incrementally improved long-term allograft and recipient outcomes. With close to 18,000 kidney transplants performed in the United States in 2015, this form of therapy is considered the treatment of choice for most patients with end-stage renal disease. Optimal care of kidney recipients requires a clear understanding of the nuances of immunosuppressive therapy tailored to each individual patient’s needs, as underdosing can lead to rejection and graft loss, whereas excessive immunosuppression can result in serious infections, malignancy, and even death.In this chapter, we present a brief historical perspective on the evolution of transplantation and immunosuppression. We discuss the importance of individualizing therapy and offer a framework for doing this. We then consider contemporary immunosuppressive therapy, summarizing individual agents, and stressing landmark trials that have led to current treatment standards. We end with a commentary on the use of generic immunosuppression, and explore emerging therapies and future prospects for immunosuppression." @default.
• W1633543075 created "2016-06-24" @default.
• W1633543075 creator A5081289232 @default.
• W1633543075 date "1978-10-01" @default.
• W1633543075 modified "2023-09-30" @default.
• W1633543075 title "Personal Reflections in Transplantation" @default.
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• W1633543075 doi "https://doi.org/10.1016/s0039-6109(16)41629-4" @default.
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