Matches in SemOpenAlex for { <https://semopenalex.org/work/W163376688> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W163376688 abstract "Proteolytic arterial remodelling is a key process in various vasculopathies including restenosis and aortic aneurysm formation. One of the candidate effector proteases in both processes, may be cathepsin K (CatK), a potent lysosomal cysteine protease. We therefore hypothesized that a deficiency of this cystein protease could protect against these vascular pathologies. Firstly, we studied the effect of CatK deficiency on the intimal hyperplasia under normo-lipidemic (CatK−/− vs WT) and hyperlipidemic conditions (CatK−/−//ApoE−/− vs ApoE−/−) as induced by permanent ligation of the right carotid artery. Average neointima formation in hyperlipidemic CatK−/−//ApoE mice was significantly reduced compared to ApoE−/− mice (64%, p=0.02). Total vessel area was also significantly reduced in CatK−/−//ApoE−/− mice (46%, p=0.008 ). In contrast, catK deficiency did not affect SMC-rich neointima formation in normolipidemic mice as there was no difference in neointima size between CatK−/− mice and WT mice of C57BL/6 background. Secondly, we investigated the effect of CatK deficiency on angiotensin II-induced aneurysm formation in ApoE−/− mice. Contrary to our expectations, CatK deficiency did not protect against murine aneurysm formation. Strikingly, despite the similar aneurysm area, collagen content of aneurism lesions was 6-fold higher in CatK−/−//ApoE mice (p=0.04). Furthermore, we noticed a compensatory 71% and 90% increase, respectively, in the percentage of cathepsin S and cathepsin C positive cells in adventitia of CatK−/−//ApoE versus ApoE−/− mice (p=0.007 and 0.013, respectively). Taken these observations together, CatK deficiency appears to have divergent effects on restenosis and aneurysm formation only conferring protecting macrophage rich neointima formation in CatK−/−//ApoE−/− mice. Despite enhancing collagen content, CatK deficiency did not reduce aneurysm formation, which may be related to compensatory activation of other cathepsins in CatK deficiency. This also suggests that novel inhibitors selectively targeting CatK to intervene in pathogenic remodelling responses should be applied with caution." @default.
- W163376688 created "2016-06-24" @default.
- W163376688 creator A5014557806 @default.
- W163376688 creator A5017817427 @default.
- W163376688 creator A5019619658 @default.
- W163376688 creator A5032467961 @default.
- W163376688 creator A5033451456 @default.
- W163376688 creator A5046965563 @default.
- W163376688 creator A5058842094 @default.
- W163376688 creator A5063305996 @default.
- W163376688 date "2008-10-28" @default.
- W163376688 modified "2023-10-17" @default.
- W163376688 title "Abstract 5490: Cathepsin K Deficiency does not Affect Murine Aneurysm Formation However it Reduces Macrophage-Rich Neointima Formation in Apoe−/−Mice" @default.
- W163376688 doi "https://doi.org/10.1161/circ.118.suppl_18.s_560" @default.
- W163376688 hasPublicationYear "2008" @default.
- W163376688 type Work @default.
- W163376688 sameAs 163376688 @default.
- W163376688 citedByCount "0" @default.
- W163376688 crossrefType "journal-article" @default.
- W163376688 hasAuthorship W163376688A5014557806 @default.
- W163376688 hasAuthorship W163376688A5017817427 @default.
- W163376688 hasAuthorship W163376688A5019619658 @default.
- W163376688 hasAuthorship W163376688A5032467961 @default.
- W163376688 hasAuthorship W163376688A5033451456 @default.
- W163376688 hasAuthorship W163376688A5046965563 @default.
- W163376688 hasAuthorship W163376688A5058842094 @default.
- W163376688 hasAuthorship W163376688A5063305996 @default.
- W163376688 hasConcept C101990758 @default.
- W163376688 hasConcept C126322002 @default.
- W163376688 hasConcept C134018914 @default.
- W163376688 hasConcept C167844969 @default.
- W163376688 hasConcept C170493617 @default.
- W163376688 hasConcept C181199279 @default.
- W163376688 hasConcept C2776033226 @default.
- W163376688 hasConcept C2776716733 @default.
- W163376688 hasConcept C2777339539 @default.
- W163376688 hasConcept C2778283817 @default.
- W163376688 hasConcept C2778583881 @default.
- W163376688 hasConcept C2779134260 @default.
- W163376688 hasConcept C55493867 @default.
- W163376688 hasConcept C57089818 @default.
- W163376688 hasConcept C71924100 @default.
- W163376688 hasConcept C86803240 @default.
- W163376688 hasConceptScore W163376688C101990758 @default.
- W163376688 hasConceptScore W163376688C126322002 @default.
- W163376688 hasConceptScore W163376688C134018914 @default.
- W163376688 hasConceptScore W163376688C167844969 @default.
- W163376688 hasConceptScore W163376688C170493617 @default.
- W163376688 hasConceptScore W163376688C181199279 @default.
- W163376688 hasConceptScore W163376688C2776033226 @default.
- W163376688 hasConceptScore W163376688C2776716733 @default.
- W163376688 hasConceptScore W163376688C2777339539 @default.
- W163376688 hasConceptScore W163376688C2778283817 @default.
- W163376688 hasConceptScore W163376688C2778583881 @default.
- W163376688 hasConceptScore W163376688C2779134260 @default.
- W163376688 hasConceptScore W163376688C55493867 @default.
- W163376688 hasConceptScore W163376688C57089818 @default.
- W163376688 hasConceptScore W163376688C71924100 @default.
- W163376688 hasConceptScore W163376688C86803240 @default.
- W163376688 hasIssue "suppl_18" @default.
- W163376688 hasLocation W1633766881 @default.
- W163376688 hasOpenAccess W163376688 @default.
- W163376688 hasPrimaryLocation W1633766881 @default.
- W163376688 hasRelatedWork W162555619 @default.
- W163376688 hasRelatedWork W163376688 @default.
- W163376688 hasRelatedWork W2001239395 @default.
- W163376688 hasRelatedWork W2019488028 @default.
- W163376688 hasRelatedWork W2095603023 @default.
- W163376688 hasRelatedWork W2149132442 @default.
- W163376688 hasRelatedWork W2360948874 @default.
- W163376688 hasRelatedWork W2391898341 @default.
- W163376688 hasRelatedWork W2399184075 @default.
- W163376688 hasRelatedWork W4236183044 @default.
- W163376688 hasVolume "118" @default.
- W163376688 isParatext "false" @default.
- W163376688 isRetracted "false" @default.
- W163376688 magId "163376688" @default.
- W163376688 workType "article" @default.