FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1633978844> ?p ?o ?g. }

• W1633978844 endingPage "603" @default.
• W1633978844 startingPage "593" @default.
• W1633978844 abstract "High mobility group box-1 (HMGB1) acts as an inflammatory mediator and has been implicated in pathophysiological damage of vascular inflammatory diseases. Ketamine, an anesthetic agent with sedative and analgesic properties, has been shown to have potent anti-inflammatory effects in a variety of models of systemic inflammation. However, the effects of ketamine on HMGB1-mediated proinflammatory responses have not been fully investigated. In the present study, we investigated the effects of ketamine on HMGB1-activated endothelial cells and explored the underlying mechanisms.Human endothelial cells were incubated with or without HMGB1 (1 μg/mL) in the presence or absence of ketamine, an nuclear factor (NF)-κB inhibitor (PDTC), anti-toll-like receptor (TLR)2/4 antibody, or small interfering RNA (siRNA). The anti-inflammatory activities of ketamine were determined by measuring solute flux, leukocyte adhesion and migration, and activation of proinflammatory proteins in HMGB1-activated endothelial cells. The effect of ketamine on TLR-2/4 and NF-κB activation was evaluated using enzyme-linked immunosorbent assays and immunofluorescence confocal microscopy assay.We found that ketamine inhibited the HMGB1-mediated barrier disruption, neutrophil adhesion and migration, and expression of cell adhesion molecules in a dose-dependent manner. Furthermore, ketamine downregulated the TLR-2 and -4, expression in HMGB1-activated endothelial cells. Treatment with ketamine also significantly inhibited the activation of TLR2/4 and the nuclear translocation of NF-κB p50/p65. Furthermore, our study shows that the HMGB1-induced release of inflammatory mediators was suppressed by PDTC, anti-TLR2/4 antibody, and siRNA.Our study has demonstrated that ketamine exerts anti-inflammatory effects in HMGB1-mediated proinflammatory responses in a dose-dependent manner. The mechanism responsible for these effects involves the TLR2/4 and NF-κB signaling pathway." @default.
• W1633978844 created "2016-06-24" @default.
• W1633978844 creator A5013878129 @default.
• W1633978844 creator A5022263793 @default.
• W1633978844 creator A5039617968 @default.
• W1633978844 creator A5063596749 @default.
• W1633978844 creator A5066911325 @default.
• W1633978844 creator A5078119049 @default.
• W1633978844 date "2016-02-01" @default.
• W1633978844 modified "2023-10-18" @default.
• W1633978844 title "Ketamine attenuates high mobility group box-1–induced inflammatory responses in endothelial cells" @default.
• W1633978844 cites W1537203455 @default.
• W1633978844 cites W1580651257 @default.
• W1633978844 cites W168035116 @default.
• W1633978844 cites W1964842906 @default.
• W1633978844 cites W1969841262 @default.
• W1633978844 cites W1974807798 @default.
• W1633978844 cites W1981132274 @default.
• W1633978844 cites W1983979973 @default.
• W1633978844 cites W1984107710 @default.
• W1633978844 cites W1995448238 @default.
• W1633978844 cites W2022519377 @default.
• W1633978844 cites W2022798707 @default.
• W1633978844 cites W2024500633 @default.
• W1633978844 cites W2025593998 @default.
• W1633978844 cites W2028294482 @default.
• W1633978844 cites W2030964049 @default.
• W1633978844 cites W2034825883 @default.
• W1633978844 cites W2050903498 @default.
• W1633978844 cites W2051948460 @default.
• W1633978844 cites W2053144700 @default.
• W1633978844 cites W2054268200 @default.
• W1633978844 cites W2054415919 @default.
• W1633978844 cites W2061163173 @default.
• W1633978844 cites W2079112084 @default.
• W1633978844 cites W2082850093 @default.
• W1633978844 cites W2083624095 @default.
• W1633978844 cites W2086058990 @default.
• W1633978844 cites W2089220950 @default.
• W1633978844 cites W2091100466 @default.
• W1633978844 cites W2094761688 @default.
• W1633978844 cites W2095113121 @default.
• W1633978844 cites W2101153911 @default.
• W1633978844 cites W2104571045 @default.
• W1633978844 cites W2114570899 @default.
• W1633978844 cites W2115206790 @default.
• W1633978844 cites W2131389808 @default.
• W1633978844 cites W2133054993 @default.
• W1633978844 cites W2145637371 @default.
• W1633978844 cites W2146446675 @default.
• W1633978844 cites W2161904954 @default.
• W1633978844 cites W2164714222 @default.
• W1633978844 cites W2321037389 @default.
• W1633978844 doi "https://doi.org/10.1016/j.jss.2015.08.032" @default.
• W1633978844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26453003" @default.
• W1633978844 hasPublicationYear "2016" @default.
• W1633978844 type Work @default.
• W1633978844 sameAs 1633978844 @default.
• W1633978844 citedByCount "10" @default.
• W1633978844 countsByYear W16339788442016 @default.
• W1633978844 countsByYear W16339788442017 @default.
• W1633978844 countsByYear W16339788442018 @default.
• W1633978844 countsByYear W16339788442019 @default.
• W1633978844 countsByYear W16339788442021 @default.
• W1633978844 countsByYear W16339788442023 @default.
• W1633978844 crossrefType "journal-article" @default.
• W1633978844 hasAuthorship W1633978844A5013878129 @default.
• W1633978844 hasAuthorship W1633978844A5022263793 @default.
• W1633978844 hasAuthorship W1633978844A5039617968 @default.
• W1633978844 hasAuthorship W1633978844A5063596749 @default.
• W1633978844 hasAuthorship W1633978844A5066911325 @default.
• W1633978844 hasAuthorship W1633978844A5078119049 @default.
• W1633978844 hasConcept C123012128 @default.
• W1633978844 hasConcept C164027704 @default.
• W1633978844 hasConcept C185592680 @default.
• W1633978844 hasConcept C202751555 @default.
• W1633978844 hasConcept C203014093 @default.
• W1633978844 hasConcept C2776914184 @default.
• W1633978844 hasConcept C2780545709 @default.
• W1633978844 hasConcept C55493867 @default.
• W1633978844 hasConcept C71924100 @default.
• W1633978844 hasConcept C86803240 @default.
• W1633978844 hasConcept C95444343 @default.
• W1633978844 hasConcept C98274493 @default.
• W1633978844 hasConceptScore W1633978844C123012128 @default.
• W1633978844 hasConceptScore W1633978844C164027704 @default.
• W1633978844 hasConceptScore W1633978844C185592680 @default.
• W1633978844 hasConceptScore W1633978844C202751555 @default.
• W1633978844 hasConceptScore W1633978844C203014093 @default.
• W1633978844 hasConceptScore W1633978844C2776914184 @default.
• W1633978844 hasConceptScore W1633978844C2780545709 @default.
• W1633978844 hasConceptScore W1633978844C55493867 @default.
• W1633978844 hasConceptScore W1633978844C71924100 @default.
• W1633978844 hasConceptScore W1633978844C86803240 @default.
• W1633978844 hasConceptScore W1633978844C95444343 @default.
• W1633978844 hasConceptScore W1633978844C98274493 @default.
• W1633978844 hasIssue "2" @default.
• W1633978844 hasLocation W16339788441 @default.

• next