FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1634443861> ?p ?o ?g. }

• W1634443861 abstract "Scaffolds composed of extracellular matrix (ECM) have been shown to promote the formation of site-specific, functional host tissue following implantation in a number of preclinical and clinical settings. However, the exact mechanisms by which ECM scaffolds are able to promote this type of tissue are unknown. Further, the ability of ECM scaffolds to successfully promote constructive tissue remodeling appears to be dependent on the methods used in their production and the applications in which they are utilized. Therefore, a comprehensive understanding of ECM scaffold characteristics and their effects upon the host response and subsequent tissue remodeling outcome is essential to the design of intelligent scaffolds for specific clinical applications.The present work investigated the effects of tissue source and chemical cross-linking upon the resulting ECM scaffolds, showing that ECM scaffold materials have distinct ultrastructural and compositional characteristics which are dependant on both the anatomic location from which the scaffolds are derived and the methods used in their production. These characteristics were also associated with distinct patterns of cell behavior in vitro. Distinct tissue remodeling outcomes were observed following implantation of a subset of these scaffold materials in a rat abdominal wall musculature reconstruction model. Acellular, non-cross-linked ECM was associated with constructive tissue remodeling while scaffolds that contained cellular components or were chemically cross-linked resulted in dense connective tissue deposition or encapsulation, respectively. Despite differences in the tissue remodeling outcome, a histologically similar population of macrophages was observed following implantation in each of these cases. Therefore, the phenotype of the macrophage population participating in the host response was investigated. It was shown that scaffolds which resulted in constructive tissue remodeling were associated with an increase in the M2 (regulatory, pro-wound healing) macrophage population, while scaffolds which resulted in the deposition of dense collagenous connective tissue or encapsulation were associated with an increase in the M1 (pro-inflammatory) macrophage population, suggesting that different macrophage populations are associated with different tissue remodeling outcomes following ECM scaffold implantation. In vitro work showed that M1 and M2 macrophages had distinct paracrine effects upon other cell populations, further suggesting distinct roles for M1 and M2 macrophages in tissue remodeling." @default.
• W1634443861 created "2016-06-24" @default.
• W1634443861 creator A5008873241 @default.
• W1634443861 date "2010-01-01" @default.
• W1634443861 modified "2023-09-27" @default.
• W1634443861 title "Constructive tissue remodeling of biologic scaffolds: A phenomenon associated with scaffold characteristics and distinctive macrophage phenotypes" @default.
• W1634443861 cites W1524961740 @default.
• W1634443861 cites W1594905954 @default.
• W1634443861 cites W1603593764 @default.
• W1634443861 cites W1689662055 @default.
• W1634443861 cites W1723227640 @default.
• W1634443861 cites W1875588079 @default.
• W1634443861 cites W1931315964 @default.
• W1634443861 cites W1963940108 @default.
• W1634443861 cites W1964413664 @default.
• W1634443861 cites W1965177570 @default.
• W1634443861 cites W1965954181 @default.
• W1634443861 cites W1968649970 @default.
• W1634443861 cites W1968925643 @default.
• W1634443861 cites W1969390542 @default.
• W1634443861 cites W1971189453 @default.
• W1634443861 cites W1972039148 @default.
• W1634443861 cites W1978133294 @default.
• W1634443861 cites W1979272007 @default.
• W1634443861 cites W1979462929 @default.
• W1634443861 cites W1980147319 @default.
• W1634443861 cites W1981924963 @default.
• W1634443861 cites W1982522802 @default.
• W1634443861 cites W1983772892 @default.
• W1634443861 cites W1986031245 @default.
• W1634443861 cites W1986141694 @default.
• W1634443861 cites W1986308133 @default.
• W1634443861 cites W1986383371 @default.
• W1634443861 cites W1986736465 @default.
• W1634443861 cites W1987732447 @default.
• W1634443861 cites W1987754486 @default.
• W1634443861 cites W1988317553 @default.
• W1634443861 cites W1992430132 @default.
• W1634443861 cites W1994495261 @default.
• W1634443861 cites W1995063875 @default.
• W1634443861 cites W1995177733 @default.
• W1634443861 cites W1995373597 @default.
• W1634443861 cites W1996929913 @default.
• W1634443861 cites W1997122966 @default.
• W1634443861 cites W1997462736 @default.
• W1634443861 cites W1997547509 @default.
• W1634443861 cites W1997830990 @default.
• W1634443861 cites W1998431553 @default.
• W1634443861 cites W1999579326 @default.
• W1634443861 cites W2000082963 @default.
• W1634443861 cites W2001581318 @default.
• W1634443861 cites W2001717792 @default.
• W1634443861 cites W2001849288 @default.
• W1634443861 cites W2002246826 @default.
• W1634443861 cites W2003275504 @default.
• W1634443861 cites W2003327793 @default.
• W1634443861 cites W2003924286 @default.
• W1634443861 cites W2006742156 @default.
• W1634443861 cites W2006742647 @default.
• W1634443861 cites W2007226914 @default.
• W1634443861 cites W2007650541 @default.
• W1634443861 cites W2007697125 @default.
• W1634443861 cites W2008466413 @default.
• W1634443861 cites W2008565536 @default.
• W1634443861 cites W2010339589 @default.
• W1634443861 cites W2012194248 @default.
• W1634443861 cites W2012406405 @default.
• W1634443861 cites W2014992823 @default.
• W1634443861 cites W2015141049 @default.
• W1634443861 cites W2016293419 @default.
• W1634443861 cites W2016639612 @default.
• W1634443861 cites W2017876250 @default.
• W1634443861 cites W2018654772 @default.
• W1634443861 cites W2018880356 @default.
• W1634443861 cites W2020378650 @default.
• W1634443861 cites W2020382590 @default.
• W1634443861 cites W2021271933 @default.
• W1634443861 cites W2023501669 @default.
• W1634443861 cites W2023659339 @default.
• W1634443861 cites W2024795009 @default.
• W1634443861 cites W2026416890 @default.
• W1634443861 cites W2026731083 @default.
• W1634443861 cites W2027911167 @default.
• W1634443861 cites W2028805384 @default.
• W1634443861 cites W2030077110 @default.
• W1634443861 cites W2031013234 @default.
• W1634443861 cites W2031856001 @default.
• W1634443861 cites W2032549615 @default.
• W1634443861 cites W2032876761 @default.
• W1634443861 cites W2035017383 @default.
• W1634443861 cites W2035072968 @default.
• W1634443861 cites W2035790993 @default.
• W1634443861 cites W2038029228 @default.
• W1634443861 cites W2038427823 @default.
• W1634443861 cites W2038747440 @default.
• W1634443861 cites W2038846800 @default.
• W1634443861 cites W2039015169 @default.
• W1634443861 cites W2041028913 @default.
• W1634443861 cites W2042248138 @default.
• W1634443861 cites W2042365433 @default.

• next