Matches in SemOpenAlex for { <https://semopenalex.org/work/W1634487747> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1634487747 endingPage "7281" @default.
- W1634487747 startingPage "7276" @default.
- W1634487747 abstract "Abstract Ribonucleoside diphosphate reductase induced in Escherichia coli by infection with bacteriophage T4 catalyzes the reduction of the 5'-diphosphates of cytidine, uridine, guanosine, and adenosine (CDP, UDP, GDP, and ADP). The specificity of the enzyme for the substrates is governed by different nucleoside triphosphates which act both by changing the maximal velocity of the reaction and the apparent Km for the substrates. Deoxyadenosine triphosphate (dATP) and ATP are the prime effectors for the reduction of the pyrimidine ribonucleotides CDP and UDP, deoxythymidine triphosphate (dTTP) is the prime effector for the reduction of GDP, and dGTP is the prime effector for the reduction of ADP. None of the nucleotides is a general inhibitor. Substrate saturation curves are hyperbolic both in the absence and presence of effector. In the presence of the prime effector the maximal velocity with each of the four substrates is of the same magnitude. The Km values for CDP, GDP, and ADP are about 0.3 mm in the absence of effector and about 0.05 mm in the presence of a prime effector. The corresponding Km values for UDP are 1.2 mm and 0.1 mm, respectively. It is suggested that the nucleoside triphosphates act by allosteric mechanisms. Competition experiments indicate that the enzyme contains a single allosteric site and a single catalytic site. The allosteric properties of T4 ribonucleotide reductase are in many ways similar to those of the E. coli enzyme. A main difference, however, concerns the effect of dATP. With the T4 enzyme this nucleotide is a prime effector for the reduction of pyrimidine ribonucleotides while it is an inhibitor for the reduction of all ribonucleotides with the E. coli enzyme." @default.
- W1634487747 created "2016-06-24" @default.
- W1634487747 creator A5027066888 @default.
- W1634487747 date "1972-11-01" @default.
- W1634487747 modified "2023-10-03" @default.
- W1634487747 title "Ribonucleoside Diphosphate Reductase Induced by Bacteriophage T4" @default.
- W1634487747 cites W1441743671 @default.
- W1634487747 cites W148800190 @default.
- W1634487747 cites W1493392505 @default.
- W1634487747 cites W1494774182 @default.
- W1634487747 cites W1540709014 @default.
- W1634487747 cites W1551022303 @default.
- W1634487747 cites W1582510195 @default.
- W1634487747 cites W1592511703 @default.
- W1634487747 cites W1671858740 @default.
- W1634487747 cites W1673365275 @default.
- W1634487747 cites W176437257 @default.
- W1634487747 cites W1885778179 @default.
- W1634487747 cites W1971422589 @default.
- W1634487747 cites W1988761948 @default.
- W1634487747 cites W2009416343 @default.
- W1634487747 cites W2018017977 @default.
- W1634487747 cites W2041883395 @default.
- W1634487747 cites W2050643839 @default.
- W1634487747 cites W2095194835 @default.
- W1634487747 cites W2107748559 @default.
- W1634487747 cites W2326197185 @default.
- W1634487747 doi "https://doi.org/10.1016/s0021-9258(19)44625-5" @default.
- W1634487747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4565081" @default.
- W1634487747 hasPublicationYear "1972" @default.
- W1634487747 type Work @default.
- W1634487747 sameAs 1634487747 @default.
- W1634487747 citedByCount "59" @default.
- W1634487747 countsByYear W16344877472015 @default.
- W1634487747 countsByYear W16344877472017 @default.
- W1634487747 countsByYear W16344877472020 @default.
- W1634487747 crossrefType "journal-article" @default.
- W1634487747 hasAuthorship W1634487747A5027066888 @default.
- W1634487747 hasBestOaLocation W16344877471 @default.
- W1634487747 hasConcept C104292427 @default.
- W1634487747 hasConcept C104317684 @default.
- W1634487747 hasConcept C185592680 @default.
- W1634487747 hasConcept C2776441376 @default.
- W1634487747 hasConcept C2776844798 @default.
- W1634487747 hasConcept C4710235 @default.
- W1634487747 hasConcept C547475151 @default.
- W1634487747 hasConcept C55493867 @default.
- W1634487747 hasConcept C67705224 @default.
- W1634487747 hasConcept C86803240 @default.
- W1634487747 hasConceptScore W1634487747C104292427 @default.
- W1634487747 hasConceptScore W1634487747C104317684 @default.
- W1634487747 hasConceptScore W1634487747C185592680 @default.
- W1634487747 hasConceptScore W1634487747C2776441376 @default.
- W1634487747 hasConceptScore W1634487747C2776844798 @default.
- W1634487747 hasConceptScore W1634487747C4710235 @default.
- W1634487747 hasConceptScore W1634487747C547475151 @default.
- W1634487747 hasConceptScore W1634487747C55493867 @default.
- W1634487747 hasConceptScore W1634487747C67705224 @default.
- W1634487747 hasConceptScore W1634487747C86803240 @default.
- W1634487747 hasIssue "22" @default.
- W1634487747 hasLocation W16344877471 @default.
- W1634487747 hasOpenAccess W1634487747 @default.
- W1634487747 hasPrimaryLocation W16344877471 @default.
- W1634487747 hasRelatedWork W1521429242 @default.
- W1634487747 hasRelatedWork W1540709014 @default.
- W1634487747 hasRelatedWork W1580450731 @default.
- W1634487747 hasRelatedWork W1634487747 @default.
- W1634487747 hasRelatedWork W1971885031 @default.
- W1634487747 hasRelatedWork W1988761948 @default.
- W1634487747 hasRelatedWork W2027148411 @default.
- W1634487747 hasRelatedWork W2067452596 @default.
- W1634487747 hasRelatedWork W2084734772 @default.
- W1634487747 hasRelatedWork W2124701454 @default.
- W1634487747 hasVolume "247" @default.
- W1634487747 isParatext "false" @default.
- W1634487747 isRetracted "false" @default.
- W1634487747 magId "1634487747" @default.
- W1634487747 workType "article" @default.