FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1634634416> ?p ?o ?g. }

• W1634634416 endingPage "16896" @default.
• W1634634416 startingPage "16880" @default.
• W1634634416 abstract "Lymphocytes express potassium channels that regulate physiological cell functions, such as activation, proliferation and migration. Expression levels of K2P5.1 (TASK2; KCNK5) channels belonging to the family of two-pore domain potassium channels have previously been correlated to the activity of autoreactive T lymphocytes in patients with multiple sclerosis and rheumatoid arthritis. In humans, K2P5.1 channels are upregulated upon T cell stimulation and influence T cell effector functions. However, a further clinical translation of targeting K2P5.1 is currently hampered by a lack of highly selective inhibitors, making it necessary to evaluate the impact of KCNK5 in established preclinical animal disease models. We here demonstrate that K2P5.1 knockout (K2P5.1-/-) mice display no significant alterations concerning T cell cytokine production, proliferation rates, surface marker molecules or signaling pathways. In an experimental model of autoimmune neuroinflammation, K2P5.1-/- mice show a comparable disease course to wild-type animals and no major changes in the peripheral immune system or CNS compartment. A compensatory upregulation of the potassium channels K2P3.1 and KV1.3 seems to counterbalance the deletion of K2P5.1. As an alternative model mimicking autoimmune neuroinflammation, experimental autoimmune encephalomyelitis in the common marmoset has been proposed, especially for testing the efficacy of new potential drugs. Initial experiments show that K2P5.1 is functionally expressed on marmoset T lymphocytes, opening up the possibility for assessing future K2P5.1-targeting drugs." @default.
• W1634634416 created "2016-06-24" @default.
• W1634634416 creator A5005103364 @default.
• W1634634416 creator A5005418771 @default.
• W1634634416 creator A5006000088 @default.
• W1634634416 creator A5034872348 @default.
• W1634634416 creator A5038373894 @default.
• W1634634416 creator A5040381414 @default.
• W1634634416 creator A5047170095 @default.
• W1634634416 creator A5063310968 @default.
• W1634634416 creator A5081434524 @default.
• W1634634416 date "2015-07-24" @default.
• W1634634416 modified "2023-09-30" @default.
• W1634634416 title "Murine K2P5.1 Deficiency Has No Impact on Autoimmune Neuroinflammation due to Compensatory K2P3.1- and KV1.3-Dependent Mechanisms" @default.
• W1634634416 cites W1963631121 @default.
• W1634634416 cites W1977976049 @default.
• W1634634416 cites W1979777433 @default.
• W1634634416 cites W1985455923 @default.
• W1634634416 cites W2003292886 @default.
• W1634634416 cites W2006006104 @default.
• W1634634416 cites W2010252923 @default.
• W1634634416 cites W2015549735 @default.
• W1634634416 cites W2027617326 @default.
• W1634634416 cites W2027717631 @default.
• W1634634416 cites W2028349009 @default.
• W1634634416 cites W2030790147 @default.
• W1634634416 cites W2037366275 @default.
• W1634634416 cites W2044103292 @default.
• W1634634416 cites W2044311517 @default.
• W1634634416 cites W2057637188 @default.
• W1634634416 cites W2060201104 @default.
• W1634634416 cites W2063021163 @default.
• W1634634416 cites W2080535356 @default.
• W1634634416 cites W2086736543 @default.
• W1634634416 cites W2089806567 @default.
• W1634634416 cites W2096051735 @default.
• W1634634416 cites W2102938498 @default.
• W1634634416 cites W2104616840 @default.
• W1634634416 cites W2107605552 @default.
• W1634634416 cites W2121879520 @default.
• W1634634416 cites W2126553380 @default.
• W1634634416 cites W2131597783 @default.
• W1634634416 cites W2138274803 @default.
• W1634634416 cites W2140499071 @default.
• W1634634416 cites W2157135516 @default.
• W1634634416 cites W2164819852 @default.
• W1634634416 doi "https://doi.org/10.3390/ijms160816880" @default.
• W1634634416 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4581175" @default.
• W1634634416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26213925" @default.
• W1634634416 hasPublicationYear "2015" @default.
• W1634634416 type Work @default.
• W1634634416 sameAs 1634634416 @default.
• W1634634416 citedByCount "4" @default.
• W1634634416 countsByYear W16346344162016 @default.
• W1634634416 countsByYear W16346344162019 @default.
• W1634634416 countsByYear W16346344162021 @default.
• W1634634416 countsByYear W16346344162023 @default.
• W1634634416 crossrefType "journal-article" @default.
• W1634634416 hasAuthorship W1634634416A5005103364 @default.
• W1634634416 hasAuthorship W1634634416A5005418771 @default.
• W1634634416 hasAuthorship W1634634416A5006000088 @default.
• W1634634416 hasAuthorship W1634634416A5034872348 @default.
• W1634634416 hasAuthorship W1634634416A5038373894 @default.
• W1634634416 hasAuthorship W1634634416A5040381414 @default.
• W1634634416 hasAuthorship W1634634416A5047170095 @default.
• W1634634416 hasAuthorship W1634634416A5063310968 @default.
• W1634634416 hasAuthorship W1634634416A5081434524 @default.
• W1634634416 hasBestOaLocation W16346344161 @default.
• W1634634416 hasConcept C104317684 @default.
• W1634634416 hasConcept C127561419 @default.
• W1634634416 hasConcept C151730666 @default.
• W1634634416 hasConcept C159654299 @default.
• W1634634416 hasConcept C169760540 @default.
• W1634634416 hasConcept C170493617 @default.
• W1634634416 hasConcept C182704531 @default.
• W1634634416 hasConcept C203014093 @default.
• W1634634416 hasConcept C2776090121 @default.
• W1634634416 hasConcept C2776453536 @default.
• W1634634416 hasConcept C2776914184 @default.
• W1634634416 hasConcept C2778486448 @default.
• W1634634416 hasConcept C2778690821 @default.
• W1634634416 hasConcept C2779075594 @default.
• W1634634416 hasConcept C2780130043 @default.
• W1634634416 hasConcept C2780640218 @default.
• W1634634416 hasConcept C54355233 @default.
• W1634634416 hasConcept C86803240 @default.
• W1634634416 hasConcept C87753298 @default.
• W1634634416 hasConcept C8891405 @default.
• W1634634416 hasConcept C95444343 @default.
• W1634634416 hasConceptScore W1634634416C104317684 @default.
• W1634634416 hasConceptScore W1634634416C127561419 @default.
• W1634634416 hasConceptScore W1634634416C151730666 @default.
• W1634634416 hasConceptScore W1634634416C159654299 @default.
• W1634634416 hasConceptScore W1634634416C169760540 @default.
• W1634634416 hasConceptScore W1634634416C170493617 @default.
• W1634634416 hasConceptScore W1634634416C182704531 @default.
• W1634634416 hasConceptScore W1634634416C203014093 @default.
• W1634634416 hasConceptScore W1634634416C2776090121 @default.

• next