FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1634654311> ?p ?o ?g. }

• W1634654311 endingPage "35" @default.
• W1634654311 startingPage "31" @default.
• W1634654311 abstract "It has been proposed that upon T cell activation, linker for activation of T cells (LAT), a transmembrane adaptor protein localized to lipid rafts, orchestrates formation of multiprotein complexes and activates signaling cascades in lipid rafts. However, whether lipid rafts really exist or function remains controversial. To address the importance of lipid rafts in LAT function, we generated a fusion protein to target LAT to nonraft fractions using the transmembrane domain from a nonraft protein, linker for activation of X cells (LAX). Surprisingly, this fusion protein functioned well in TCR signaling. It restored MAPK activation, calcium flux, and NFAT activation in LAT-deficient cells. To further study the function of this fusion protein in vivo, we generated transgenic mice that express this protein. Analysis of these mice indicated that it was fully capable of replacing LAT in thymocyte development and T cell function. Our results demonstrate that LAT localization to lipid rafts is not essential during normal T cell activation and development." @default.
• W1634654311 created "2016-06-24" @default.
• W1634654311 creator A5004418185 @default.
• W1634654311 creator A5021293751 @default.
• W1634654311 creator A5025345959 @default.
• W1634654311 creator A5039044513 @default.
• W1634654311 creator A5060356324 @default.
• W1634654311 date "2005-01-01" @default.
• W1634654311 modified "2023-09-29" @default.
• W1634654311 title "Cutting Edge: Localization of Linker for Activation of T Cells to Lipid Rafts Is Not Essential in T Cell Activation and Development" @default.
• W1634654311 cites W1804861156 @default.
• W1634654311 cites W1973272679 @default.
• W1634654311 cites W1974788802 @default.
• W1634654311 cites W2004668797 @default.
• W1634654311 cites W2014099261 @default.
• W1634654311 cites W2014177218 @default.
• W1634654311 cites W2065886456 @default.
• W1634654311 cites W2068504553 @default.
• W1634654311 cites W2079515412 @default.
• W1634654311 cites W2115037258 @default.
• W1634654311 cites W2121936687 @default.
• W1634654311 cites W2131423590 @default.
• W1634654311 cites W2141367941 @default.
• W1634654311 cites W2170885541 @default.
• W1634654311 cites W82875452 @default.
• W1634654311 cites W95054676 @default.
• W1634654311 doi "https://doi.org/10.4049/jimmunol.174.1.31" @default.
• W1634654311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15611224" @default.
• W1634654311 hasPublicationYear "2005" @default.
• W1634654311 type Work @default.
• W1634654311 sameAs 1634654311 @default.
• W1634654311 citedByCount "50" @default.
• W1634654311 countsByYear W16346543112012 @default.
• W1634654311 countsByYear W16346543112013 @default.
• W1634654311 countsByYear W16346543112014 @default.
• W1634654311 countsByYear W16346543112015 @default.
• W1634654311 countsByYear W16346543112016 @default.
• W1634654311 countsByYear W16346543112018 @default.
• W1634654311 countsByYear W16346543112019 @default.
• W1634654311 countsByYear W16346543112021 @default.
• W1634654311 crossrefType "journal-article" @default.
• W1634654311 hasAuthorship W1634654311A5004418185 @default.
• W1634654311 hasAuthorship W1634654311A5021293751 @default.
• W1634654311 hasAuthorship W1634654311A5025345959 @default.
• W1634654311 hasAuthorship W1634654311A5039044513 @default.
• W1634654311 hasAuthorship W1634654311A5060356324 @default.
• W1634654311 hasBestOaLocation W16346543111 @default.
• W1634654311 hasConcept C104317684 @default.
• W1634654311 hasConcept C123894998 @default.
• W1634654311 hasConcept C170493617 @default.
• W1634654311 hasConcept C183786373 @default.
• W1634654311 hasConcept C185592680 @default.
• W1634654311 hasConcept C189938988 @default.
• W1634654311 hasConcept C19317047 @default.
• W1634654311 hasConcept C203014093 @default.
• W1634654311 hasConcept C24530287 @default.
• W1634654311 hasConcept C2776090121 @default.
• W1634654311 hasConcept C40767141 @default.
• W1634654311 hasConcept C55493867 @default.
• W1634654311 hasConcept C62478195 @default.
• W1634654311 hasConcept C79266657 @default.
• W1634654311 hasConcept C86339819 @default.
• W1634654311 hasConcept C86803240 @default.
• W1634654311 hasConcept C8891405 @default.
• W1634654311 hasConcept C95444343 @default.
• W1634654311 hasConceptScore W1634654311C104317684 @default.
• W1634654311 hasConceptScore W1634654311C123894998 @default.
• W1634654311 hasConceptScore W1634654311C170493617 @default.
• W1634654311 hasConceptScore W1634654311C183786373 @default.
• W1634654311 hasConceptScore W1634654311C185592680 @default.
• W1634654311 hasConceptScore W1634654311C189938988 @default.
• W1634654311 hasConceptScore W1634654311C19317047 @default.
• W1634654311 hasConceptScore W1634654311C203014093 @default.
• W1634654311 hasConceptScore W1634654311C24530287 @default.
• W1634654311 hasConceptScore W1634654311C2776090121 @default.
• W1634654311 hasConceptScore W1634654311C40767141 @default.
• W1634654311 hasConceptScore W1634654311C55493867 @default.
• W1634654311 hasConceptScore W1634654311C62478195 @default.
• W1634654311 hasConceptScore W1634654311C79266657 @default.
• W1634654311 hasConceptScore W1634654311C86339819 @default.
• W1634654311 hasConceptScore W1634654311C86803240 @default.
• W1634654311 hasConceptScore W1634654311C8891405 @default.
• W1634654311 hasConceptScore W1634654311C95444343 @default.
• W1634654311 hasIssue "1" @default.
• W1634654311 hasLocation W16346543111 @default.
• W1634654311 hasLocation W16346543112 @default.
• W1634654311 hasOpenAccess W1634654311 @default.
• W1634654311 hasPrimaryLocation W16346543111 @default.
• W1634654311 hasRelatedWork W138661586 @default.
• W1634654311 hasRelatedWork W1581934447 @default.
• W1634654311 hasRelatedWork W1634654311 @default.
• W1634654311 hasRelatedWork W1950561235 @default.
• W1634654311 hasRelatedWork W2032680134 @default.
• W1634654311 hasRelatedWork W2074628296 @default.
• W1634654311 hasRelatedWork W2104636614 @default.
• W1634654311 hasRelatedWork W2153762242 @default.
• W1634654311 hasRelatedWork W4313379015 @default.
• W1634654311 hasRelatedWork W4211147462 @default.

• next