FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1634845388> ?p ?o ?g. }

• W1634845388 endingPage "1821" @default.
• W1634845388 startingPage "1812" @default.
• W1634845388 abstract "Abstract Lymphangioleiomyomatosis (LAM) is a progressive disease caused by accumulation of metastatic (LAM) cells in the lungs, lymphatics, and the tumor angiomyolipoma (AML). LAM cells have biallelic loss of either tuberous sclerosis complex gene (but predominantly TSC-2) and resultant dysregulation of the mammalian target of rapamycin (mTOR) pathway. Chemokines are associated with neoplastic cell growth, survival, and homing to specific organs and may play similar roles in LAM. Our objective was to study comprehensively the expression and function of chemokine receptors and how their function interacts with dysregulation of the mTOR pathway in LAM and AML. We used RT-PCR and FACS to study receptor expression in primary AML cells and immunohistochemistry to investigate expression in tissues. Chemokine receptor function was analyzed in AML cells by Western blotting of signaling proteins and cell proliferation and apoptosis assays. Primary AML cells, LAM, and AML tissues expressed CCR3, CXCR4, CXCR6, and CXC3CR1. In AML cells, their ligands CXCL12 CX3CL1, CCL11, CCL24, and CCL28 caused robust phosphorylation of p42/44 MAPK and Akt. CXCL12 was expressed in type II pneumocytes covering LAM nodules and caused AML cell growth and protection from apoptosis, which was blocked by AMD3100, a CXCR4 inhibitor. The mTOR inhibitor rapamycin, but not AMD3100, inhibited growth of AML tumor xenografts. We conclude that the CXCL12/CXCR4 axis promotes, but is not absolutely required for, AML/LAM cell growth and survival." @default.
• W1634845388 created "2016-06-24" @default.
• W1634845388 creator A5017673380 @default.
• W1634845388 creator A5039472712 @default.
• W1634845388 creator A5081781260 @default.
• W1634845388 creator A5086446396 @default.
• W1634845388 date "2010-08-01" @default.
• W1634845388 modified "2023-09-28" @default.
• W1634845388 title "Role of the CXCR4/CXCL12 Axis in Lymphangioleiomyomatosis and Angiomyolipoma" @default.
• W1634845388 cites W1504612940 @default.
• W1634845388 cites W1809740262 @default.
• W1634845388 cites W1882790390 @default.
• W1634845388 cites W1978796256 @default.
• W1634845388 cites W1986346193 @default.
• W1634845388 cites W1995095891 @default.
• W1634845388 cites W2011063821 @default.
• W1634845388 cites W2019486812 @default.
• W1634845388 cites W2027056512 @default.
• W1634845388 cites W2029271656 @default.
• W1634845388 cites W2031650264 @default.
• W1634845388 cites W2032555040 @default.
• W1634845388 cites W2032601727 @default.
• W1634845388 cites W2038028072 @default.
• W1634845388 cites W2040662861 @default.
• W1634845388 cites W2041525705 @default.
• W1634845388 cites W2045886202 @default.
• W1634845388 cites W2050790870 @default.
• W1634845388 cites W2053241990 @default.
• W1634845388 cites W2054043672 @default.
• W1634845388 cites W2063503035 @default.
• W1634845388 cites W2068298220 @default.
• W1634845388 cites W2086524655 @default.
• W1634845388 cites W2088873819 @default.
• W1634845388 cites W2097471654 @default.
• W1634845388 cites W2100033186 @default.
• W1634845388 cites W2100499764 @default.
• W1634845388 cites W2101421826 @default.
• W1634845388 cites W2102790879 @default.
• W1634845388 cites W2103766839 @default.
• W1634845388 cites W2112339107 @default.
• W1634845388 cites W2117690071 @default.
• W1634845388 cites W2118099074 @default.
• W1634845388 cites W2119700701 @default.
• W1634845388 cites W2131601314 @default.
• W1634845388 cites W2135908106 @default.
• W1634845388 cites W2136776237 @default.
• W1634845388 cites W2146473759 @default.
• W1634845388 cites W2152339200 @default.
• W1634845388 cites W2153417161 @default.
• W1634845388 cites W2158672961 @default.
• W1634845388 cites W2160272188 @default.
• W1634845388 cites W2168811058 @default.
• W1634845388 cites W2170936754 @default.
• W1634845388 cites W2184718406 @default.
• W1634845388 cites W4210980116 @default.
• W1634845388 cites W4237534021 @default.
• W1634845388 cites W4238356169 @default.
• W1634845388 cites W4252082388 @default.
• W1634845388 cites W4295813358 @default.
• W1634845388 doi "https://doi.org/10.4049/jimmunol.0902149" @default.
• W1634845388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20585037" @default.
• W1634845388 hasPublicationYear "2010" @default.
• W1634845388 type Work @default.
• W1634845388 sameAs 1634845388 @default.
• W1634845388 citedByCount "16" @default.
• W1634845388 countsByYear W16348453882012 @default.
• W1634845388 countsByYear W16348453882013 @default.
• W1634845388 countsByYear W16348453882014 @default.
• W1634845388 countsByYear W16348453882015 @default.
• W1634845388 countsByYear W16348453882016 @default.
• W1634845388 countsByYear W16348453882017 @default.
• W1634845388 countsByYear W16348453882018 @default.
• W1634845388 countsByYear W16348453882021 @default.
• W1634845388 countsByYear W16348453882022 @default.
• W1634845388 crossrefType "journal-article" @default.
• W1634845388 hasAuthorship W1634845388A5017673380 @default.
• W1634845388 hasAuthorship W1634845388A5039472712 @default.
• W1634845388 hasAuthorship W1634845388A5081781260 @default.
• W1634845388 hasAuthorship W1634845388A5086446396 @default.
• W1634845388 hasBestOaLocation W16348453881 @default.
• W1634845388 hasConcept C12823836 @default.
• W1634845388 hasConcept C129470790 @default.
• W1634845388 hasConcept C13373296 @default.
• W1634845388 hasConcept C142724271 @default.
• W1634845388 hasConcept C203014093 @default.
• W1634845388 hasConcept C2778980267 @default.
• W1634845388 hasConcept C2779997425 @default.
• W1634845388 hasConcept C502942594 @default.
• W1634845388 hasConcept C54355233 @default.
• W1634845388 hasConcept C62112901 @default.
• W1634845388 hasConcept C62478195 @default.
• W1634845388 hasConcept C71924100 @default.
• W1634845388 hasConcept C75217442 @default.
• W1634845388 hasConcept C86554907 @default.
• W1634845388 hasConcept C86803240 @default.
• W1634845388 hasConcept C8891405 @default.
• W1634845388 hasConcept C95444343 @default.
• W1634845388 hasConceptScore W1634845388C12823836 @default.

• next