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• W1634856761 abstract "SUMMARYThe aminoacid L-Arginine being the sole donor of nitricoxide synthesis in cases of intestinal ischemia, seems toplay a protective role during experimental acute colonischemia and reperfusion. We studied the effect of pretreatmentwith the aminoacid L-arginine in 144 Wistar rats whowere subjected to experimental acute ischemic colitis(A.I.C.) and reperfusion of varying time periods (30, 60, 90minutes). L-arginine was studied in comparison with Molcydomineand Caseine, two substances used for intestinalprotection. Serum malondialdehyde (MDA) levels, a reliablemarker which indicate the degree of tissue damage afterischemia-reperfusion, were lower in the L-argininegroup, while the same group presented the lower level ofhistopathological damages. We conclude that pretreatmentwith L-arginine in rats subjected to A.I.C. attenuates thehistopathophysiological damages.Key words: L-Arginine, Reperfusion injury, Intestinalischemia, Malondialdehyde, Experimental model." @default.
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• W1634856761 date "2001-01-01" @default.
• W1634856761 modified "2023-09-27" @default.
• W1634856761 title "The prophylactic effect of L-Arginine in an experimental model of acute ischemic colitis. A histopathological and biochemical (malondialdehyde levels) evaluation" @default.
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