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- W163520811 abstract "The chapter reviews recent findings on the biology of the eosinophil, particularly distinctive eosinophil features, and discusses the possible role of the eosinophil in the pathogenesis of certain diseases with which the cell is associated. There is evidence that eosinophils slow the rate of progression of solid tumors through tumoricidal mechanisms. There is no experiment of nature in that cell, or its progenitors are selectively depleted; and at the present time no pharmacological or biological inhibitor is available for laboratory-based or clinical studies. However, in the past few years, evidence has shifted away from the cell having anti-allergic properties, and even its role in adaptive immunity to helminth infections is seriously questioned. It is important to bear in mind that the eosinophil is an inflammatory cell and that the purpose of inflammation is to restore, repair, and remodel injured tissue. The role of the eosinophil in wound healing has recently received considerable attention, and it seems reasonable to expect that this will be a growth area for eosinophil biologists. Intriguingly, there is now some firm data to implicate the eosinophil in immunological responses against cancer cells. The recent findings on the potential of eosinophils in cancer immunity may stimulate a better understanding of the role of this cell type. It can be stated with reasonable assurity that the eosinophil probably has some homeostatic function in certain physiological situations and that this needs to be considered further." @default.
- W163520811 created "2016-06-24" @default.
- W163520811 creator A5013596629 @default.
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- W163520811 date "1995-01-01" @default.
- W163520811 modified "2023-09-25" @default.
- W163520811 title "Eosinophils: Biology and Role in Disease" @default.
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