FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W163531479> ?p ?o ?g. }

• W163531479 endingPage "422" @default.
• W163531479 startingPage "414" @default.
• W163531479 abstract "Nonstructural protein 1 (NS1) of influenza A viruses counteracts the host immune response against the influenza viruses by not only inhibiting the nuclear export and maturation of host cell messenger RNA (mRNA), but by also blocking the double-stranded RNA–activated protein kinase–mediated inhibition of viral RNA translation. Reduction of NS1 gene product in the host cell may be a potent antiviral strategy to provide protection against the influenza virus infection. We used small interfering RNAs (siRNAs) synthesized against the viral mRNA to down regulate the NS1 gene and observed its effect on inhibition of virus replication. When NS1 gene–specific siRNA were transfected in Madin Darby canine kidney (MDCK) cells followed by influenza A virus infection, approximately 60% inhibition in intracellular levels of NS1 RNA was observed. When siRNA was administered in BALB/c mice, 92% reduction in the levels of NS1 gene expression in mice lungs was observed. A significant reduction in the lung virus titers and cytokine levels was also detected in the presence of siRNAs as compared with the untreated control. The study was validated by the use of selectively disabled mutants of each set of siRNA. Our findings suggest that siRNA targeted against NS1 gene of influenza A virus can provide considerable protection to the virus-infected host cells and may be used as potential candidates for nucleic acid–based antiviral therapy for prevention of influenza A virus infection." @default.
• W163531479 created "2016-06-24" @default.
• W163531479 creator A5003086301 @default.
• W163531479 creator A5023547557 @default.
• W163531479 creator A5023860941 @default.
• W163531479 creator A5029166175 @default.
• W163531479 creator A5038199614 @default.
• W163531479 creator A5084973502 @default.
• W163531479 creator A5087044969 @default.
• W163531479 date "2012-12-01" @default.
• W163531479 modified "2023-09-23" @default.
• W163531479 title "Small Interfering RNA Targeting the Nonstructural Gene 1 Transcript Inhibits Influenza A Virus Replication in Experimental Mice" @default.
• W163531479 cites W1597953111 @default.
• W163531479 cites W1611419331 @default.
• W163531479 cites W1854023115 @default.
• W163531479 cites W1916491745 @default.
• W163531479 cites W1964424066 @default.
• W163531479 cites W1965785485 @default.
• W163531479 cites W1970834446 @default.
• W163531479 cites W1983489347 @default.
• W163531479 cites W1990810479 @default.
• W163531479 cites W1992569957 @default.
• W163531479 cites W1999293623 @default.
• W163531479 cites W2006635133 @default.
• W163531479 cites W2008332711 @default.
• W163531479 cites W2008696493 @default.
• W163531479 cites W2013286203 @default.
• W163531479 cites W2032323486 @default.
• W163531479 cites W2034649150 @default.
• W163531479 cites W2038698914 @default.
• W163531479 cites W2039933877 @default.
• W163531479 cites W2043175663 @default.
• W163531479 cites W2043349477 @default.
• W163531479 cites W2049699095 @default.
• W163531479 cites W2050776627 @default.
• W163531479 cites W2055928868 @default.
• W163531479 cites W2062364477 @default.
• W163531479 cites W2063107058 @default.
• W163531479 cites W2065550185 @default.
• W163531479 cites W2078635213 @default.
• W163531479 cites W2088650511 @default.
• W163531479 cites W2089595052 @default.
• W163531479 cites W2091080506 @default.
• W163531479 cites W2091151415 @default.
• W163531479 cites W2098100188 @default.
• W163531479 cites W2098472306 @default.
• W163531479 cites W2106367530 @default.
• W163531479 cites W2124559804 @default.
• W163531479 cites W2129205448 @default.
• W163531479 cites W2138498894 @default.
• W163531479 cites W2139268538 @default.
• W163531479 cites W2157836977 @default.
• W163531479 cites W2158110042 @default.
• W163531479 cites W2163853272 @default.
• W163531479 cites W2163903730 @default.
• W163531479 cites W2164029923 @default.
• W163531479 doi "https://doi.org/10.1089/nat.2012.0359" @default.
• W163531479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23062009" @default.
• W163531479 hasPublicationYear "2012" @default.
• W163531479 type Work @default.
• W163531479 sameAs 163531479 @default.
• W163531479 citedByCount "22" @default.
• W163531479 countsByYear W1635314792013 @default.
• W163531479 countsByYear W1635314792014 @default.
• W163531479 countsByYear W1635314792015 @default.
• W163531479 countsByYear W1635314792016 @default.
• W163531479 countsByYear W1635314792017 @default.
• W163531479 countsByYear W1635314792018 @default.
• W163531479 countsByYear W1635314792019 @default.
• W163531479 countsByYear W1635314792020 @default.
• W163531479 countsByYear W1635314792021 @default.
• W163531479 crossrefType "journal-article" @default.
• W163531479 hasAuthorship W163531479A5003086301 @default.
• W163531479 hasAuthorship W163531479A5023547557 @default.
• W163531479 hasAuthorship W163531479A5023860941 @default.
• W163531479 hasAuthorship W163531479A5029166175 @default.
• W163531479 hasAuthorship W163531479A5038199614 @default.
• W163531479 hasAuthorship W163531479A5084973502 @default.
• W163531479 hasAuthorship W163531479A5087044969 @default.
• W163531479 hasConcept C104317684 @default.
• W163531479 hasConcept C105580179 @default.
• W163531479 hasConcept C140704245 @default.
• W163531479 hasConcept C150194340 @default.
• W163531479 hasConcept C153911025 @default.
• W163531479 hasConcept C159047783 @default.
• W163531479 hasConcept C166703698 @default.
• W163531479 hasConcept C22615655 @default.
• W163531479 hasConcept C2522874641 @default.
• W163531479 hasConcept C2777546802 @default.
• W163531479 hasConcept C54009773 @default.
• W163531479 hasConcept C55493867 @default.
• W163531479 hasConcept C67705224 @default.
• W163531479 hasConcept C86803240 @default.
• W163531479 hasConceptScore W163531479C104317684 @default.
• W163531479 hasConceptScore W163531479C105580179 @default.
• W163531479 hasConceptScore W163531479C140704245 @default.
• W163531479 hasConceptScore W163531479C150194340 @default.
• W163531479 hasConceptScore W163531479C153911025 @default.

• next