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- W163549757 abstract "Pesticide poisoning, accidental or intentional self-poisoning is a signicant problem in many parts of the developing world. Paraquat is a compound that has been widely used as a non-selective contact herbicide since 1962. Ingestion of paraquat is a signicant method of self-poisoning in parts of Asia, Pacic islands, and Caribbean. Ingestion of large amounts is considered to be uniformly fatal, resulting in death from multi-organ; however, in smaller quantities, paraquat is specically taken up into and accumulates in the lung, and the redox cycling and free radical generation triggers a neutrophil-mediated inammatory response in the lungs which initiates an irreversiblebrotic process that kills the majority of patients within several weeks. In this work, was studied the ability of thiamine to protect against Paraquat (PQ)-induced mortality and oxidative damage in rat liver. The medial lethal dose (LD 50 ) for PQ was 32 mg/kg of body weight within 48 h. When thiamine (100 mg/kg) was administrated to PQ-treated rats, mortality was not observed. However, thiamine at 200 mg/kg did not modify mortality. For the oxidative stress study, the liver was obtained 24" @default.
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- W163549757 date "2012-01-01" @default.
- W163549757 modified "2023-09-27" @default.
- W163549757 title "Intoxicación por herbicida y el uso de la Tiamina. Un estudio experimental" @default.
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