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- W1635516821 abstract "Aim To observe the effect of minocycline against Toxoplasma tachyzoites in vitro. Methods After the inoculation of Toxoplasma gondii (RH strain) tachyzoites into the cultured HeLa cells, the culture was treated with different concentration of minocycline or the combnation of minocycline and pyrimethamine, at the same time, the positive and negative control groups were set up. Forty eight to 96 h later, the cultured cells were taken out, fixed and stained. The infected rate and the number of Toxoplasma tachyzoite per parasitophorous vacuole were observed. Result The effect of minocycline against Toxoplasma was quite satisfactory, and the parasiticidal effect was positively related to the concentration of the drug, but when prolonged the drug treatment time to 96h,the effect was not better than 72h group. The combination of minocycline and pyrimethamine was the most effective and the parasites could be killed totally. Conclusion Minocycline is a good anti-toxoplasma drug and the joint treatment of monocycline with pyrimethamine can get more satisfactory effect." @default.
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- W1635516821 date "2000-01-01" @default.
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- W1635516821 title "Effect of minocycline against Toxoplasma tachyzoite in vitro." @default.
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