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- W1635631226 endingPage "25" @default.
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- W1635631226 abstract "Abstract Development of a therapeutic agent is a long and laborious process commencing with the discovery of a “druggable target” underlying the pathology of a disease. After rigorous testing, optimization, and modification, the candidate agent is then carefully tested for toxicity in appropriate animal models to define a dose that can be safely administered to human patients without adverse effects. Once these preclinical studies have been performed, the experiemental drug moves into the clinical trials phases. Phase I clinical trials are typically dose escalation studies meant to evaluate the safety, adverse events, and maximum tolerated dose in human patients. Agents that appear to be reasonably safe then progress to phase II and eventually phase III studies to evaluate their efficacy prior to government approval and marketing. In this chapter we will discuss three recently approved agents that have been through this process and are now being tested in combination with other therapies and one experimental agent that is actively engaged in the developmental process." @default.
- W1635631226 created "2016-06-24" @default.
- W1635631226 creator A5032094154 @default.
- W1635631226 creator A5041131555 @default.
- W1635631226 creator A5081558605 @default.
- W1635631226 date "2011-12-16" @default.
- W1635631226 modified "2023-10-17" @default.
- W1635631226 title "From Concept to the Clinics: Development of Cancer Therapeutics" @default.
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