FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1635638240> ?p ?o ?g. }

• W1635638240 endingPage "3175" @default.
• W1635638240 startingPage "3166" @default.
• W1635638240 abstract "Abstract Dendritic cell (DC) differentiation is abnormal in type 1 diabetes mellitus (T1DM). However, the nature of the relationship between this abnormality and disease pathogenesis is unknown. We studied the LPS response in monocytes and monocyte-derived DCs isolated from T1DM patients and from non-T1DM controls. In T1DM patients, late LPS-mediated nuclear DNA binding by RelA, p50, c-Rel, and RelB was impaired as compared with type 2 DM, rheumatoid arthritis, and healthy subjects, associated with impaired DC CD40 and MHC class I induction but normal cytokine production. In TIDM monocytes, RelA and RelB were constitutively activated, and the src homology 2 domain-containing protein tyrosine phosphatase (SHP-1), a negative regulator of NF-κB, was overexpressed. Addition of sodium stibogluconate, a SHP-1 inhibitor, to DCs differentiating from monocyte precursors restored their capacity to respond to LPS in ∼60% of patients. The monocyte and DC NF-κB response to LPS is thus a novel phenotypic and likely pathogenetic marker for human T1DM. SHP-1 is at least one NF-κB regulatory mechanism which might be induced as a result of abnormal inflammatory signaling responses in T1DM monocytes." @default.
• W1635638240 created "2016-06-24" @default.
• W1635638240 creator A5000799247 @default.
• W1635638240 creator A5007707209 @default.
• W1635638240 creator A5027632335 @default.
• W1635638240 creator A5032762197 @default.
• W1635638240 creator A5044211360 @default.
• W1635638240 creator A5045209417 @default.
• W1635638240 creator A5046338402 @default.
• W1635638240 creator A5050417334 @default.
• W1635638240 creator A5063681577 @default.
• W1635638240 creator A5076462020 @default.
• W1635638240 date "2008-03-01" @default.
• W1635638240 modified "2023-09-27" @default.
• W1635638240 title "Abnormal NF-κB Function Characterizes Human Type 1 Diabetes Dendritic Cells and Monocytes" @default.
• W1635638240 cites W1525912444 @default.
• W1635638240 cites W1553847148 @default.
• W1635638240 cites W1561535731 @default.
• W1635638240 cites W1588586944 @default.
• W1635638240 cites W1612419598 @default.
• W1635638240 cites W1622219374 @default.
• W1635638240 cites W1669694727 @default.
• W1635638240 cites W1694093395 @default.
• W1635638240 cites W1884132335 @default.
• W1635638240 cites W1971692004 @default.
• W1635638240 cites W1972360982 @default.
• W1635638240 cites W1976564408 @default.
• W1635638240 cites W1982906491 @default.
• W1635638240 cites W1984993017 @default.
• W1635638240 cites W1986102510 @default.
• W1635638240 cites W1992856202 @default.
• W1635638240 cites W1993948601 @default.
• W1635638240 cites W1994527192 @default.
• W1635638240 cites W1997050095 @default.
• W1635638240 cites W1997055154 @default.
• W1635638240 cites W1997334983 @default.
• W1635638240 cites W2001944699 @default.
• W1635638240 cites W2007639150 @default.
• W1635638240 cites W2013730613 @default.
• W1635638240 cites W2015875235 @default.
• W1635638240 cites W2018718597 @default.
• W1635638240 cites W2030250764 @default.
• W1635638240 cites W2033810895 @default.
• W1635638240 cites W2039687845 @default.
• W1635638240 cites W2040620327 @default.
• W1635638240 cites W2043150560 @default.
• W1635638240 cites W2045758494 @default.
• W1635638240 cites W2045994440 @default.
• W1635638240 cites W2048114019 @default.
• W1635638240 cites W2049080353 @default.
• W1635638240 cites W2051923563 @default.
• W1635638240 cites W2053919119 @default.
• W1635638240 cites W2056175166 @default.
• W1635638240 cites W2056402897 @default.
• W1635638240 cites W2069759825 @default.
• W1635638240 cites W2074600119 @default.
• W1635638240 cites W2076610281 @default.
• W1635638240 cites W2076980233 @default.
• W1635638240 cites W2083826829 @default.
• W1635638240 cites W2087634948 @default.
• W1635638240 cites W2095483193 @default.
• W1635638240 cites W2099888440 @default.
• W1635638240 cites W2104440648 @default.
• W1635638240 cites W2117300808 @default.
• W1635638240 cites W2127440050 @default.
• W1635638240 cites W2129455656 @default.
• W1635638240 cites W2134743445 @default.
• W1635638240 cites W2137473611 @default.
• W1635638240 cites W2139167487 @default.
• W1635638240 cites W2140944306 @default.
• W1635638240 cites W2143899077 @default.
• W1635638240 cites W2144598411 @default.
• W1635638240 cites W2146045246 @default.
• W1635638240 cites W2148096192 @default.
• W1635638240 cites W2148507130 @default.
• W1635638240 cites W2149513114 @default.
• W1635638240 cites W2155229523 @default.
• W1635638240 cites W2163595252 @default.
• W1635638240 cites W4244737180 @default.
• W1635638240 doi "https://doi.org/10.4049/jimmunol.180.5.3166" @default.
• W1635638240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18292540" @default.
• W1635638240 hasPublicationYear "2008" @default.
• W1635638240 type Work @default.
• W1635638240 sameAs 1635638240 @default.
• W1635638240 citedByCount "62" @default.
• W1635638240 countsByYear W16356382402012 @default.
• W1635638240 countsByYear W16356382402013 @default.
• W1635638240 countsByYear W16356382402014 @default.
• W1635638240 countsByYear W16356382402015 @default.
• W1635638240 countsByYear W16356382402016 @default.
• W1635638240 countsByYear W16356382402017 @default.
• W1635638240 countsByYear W16356382402018 @default.
• W1635638240 countsByYear W16356382402019 @default.
• W1635638240 countsByYear W16356382402020 @default.
• W1635638240 countsByYear W16356382402021 @default.
• W1635638240 countsByYear W16356382402022 @default.
• W1635638240 countsByYear W16356382402023 @default.
• W1635638240 crossrefType "journal-article" @default.

• next