Matches in SemOpenAlex for { <https://semopenalex.org/work/W1635738393> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1635738393 endingPage "2347" @default.
- W1635738393 startingPage "2343" @default.
- W1635738393 abstract "The peptide hormone, prolactin, when added to organ explants of rat mammary gland, rapidly (within 1 h) induced the accumulation of casein mRNA. Casein mRNA sequences, as determined by hybridization with a specific cDNA probe, were shown to increase for up to 48 h after prolactin addition. The magnitude of this response was dependent upon the day of pregnancy at which the tissue was placed in culture. Maximal levels of induction (as great as 45-fold) were obtained using tissue from 15-day pregnant rats. Further data indicate that two steroid hormones, hydrocortisone and progesterone, were able to modulate the prolactin-induced accumulation of casein mRNA. The continuous presence of hydrocortisone was not necessary for prolactin induction of casein mRNA. However, the presence of hydrocortisone was required for maximal accumulation of casein mRNA. The induction of casein mRNA by prolactin was inhibited in a dose-dependent manner by the simultaneous addition of progesterone to the organ culture. Thus, hydrocortisone appears to potentiate the prolactin induction of casein mRNA, whereas progesterone is able to prevent casein mRNA accumulation. Since mammary gland organ culture is performed in a serum-free, chemically defined medium, this system allows a detailed examination of the mechanims by which a peptide hormone regulates the rapid accumulation of a specific mRNA." @default.
- W1635738393 created "2016-06-24" @default.
- W1635738393 creator A5086412465 @default.
- W1635738393 creator A5087285670 @default.
- W1635738393 date "1978-04-01" @default.
- W1635738393 modified "2023-10-16" @default.
- W1635738393 title "Prolactin induction of casein mRNA in organ culture. A model system for studying peptide hormone regulation of gene expression." @default.
- W1635738393 cites W1496960451 @default.
- W1635738393 cites W1515245060 @default.
- W1635738393 cites W1527744735 @default.
- W1635738393 cites W1564149955 @default.
- W1635738393 cites W1598101055 @default.
- W1635738393 cites W184029216 @default.
- W1635738393 cites W1965674339 @default.
- W1635738393 cites W1966034374 @default.
- W1635738393 cites W1967142578 @default.
- W1635738393 cites W1971854296 @default.
- W1635738393 cites W1994177108 @default.
- W1635738393 cites W1995932704 @default.
- W1635738393 cites W2000533630 @default.
- W1635738393 cites W2032353642 @default.
- W1635738393 cites W2037152584 @default.
- W1635738393 cites W2037763418 @default.
- W1635738393 cites W2044163321 @default.
- W1635738393 cites W2047570451 @default.
- W1635738393 cites W2059597550 @default.
- W1635738393 cites W2078420347 @default.
- W1635738393 cites W2082135492 @default.
- W1635738393 cites W2082422179 @default.
- W1635738393 cites W2083138958 @default.
- W1635738393 cites W2088913344 @default.
- W1635738393 cites W2090686533 @default.
- W1635738393 cites W2119102012 @default.
- W1635738393 cites W2145819211 @default.
- W1635738393 cites W2164188238 @default.
- W1635738393 cites W2460346989 @default.
- W1635738393 cites W3027952176 @default.
- W1635738393 cites W4233381584 @default.
- W1635738393 doi "https://doi.org/10.1016/s0021-9258(17)38079-1" @default.
- W1635738393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/632273" @default.
- W1635738393 hasPublicationYear "1978" @default.
- W1635738393 type Work @default.
- W1635738393 sameAs 1635738393 @default.
- W1635738393 citedByCount "110" @default.
- W1635738393 countsByYear W16357383932012 @default.
- W1635738393 crossrefType "journal-article" @default.
- W1635738393 hasAuthorship W1635738393A5086412465 @default.
- W1635738393 hasAuthorship W1635738393A5087285670 @default.
- W1635738393 hasBestOaLocation W16357383931 @default.
- W1635738393 hasConcept C104317684 @default.
- W1635738393 hasConcept C105580179 @default.
- W1635738393 hasConcept C134018914 @default.
- W1635738393 hasConcept C150194340 @default.
- W1635738393 hasConcept C165864922 @default.
- W1635738393 hasConcept C202751555 @default.
- W1635738393 hasConcept C2779064019 @default.
- W1635738393 hasConcept C28483552 @default.
- W1635738393 hasConcept C55493867 @default.
- W1635738393 hasConcept C56191518 @default.
- W1635738393 hasConcept C71315377 @default.
- W1635738393 hasConcept C86803240 @default.
- W1635738393 hasConceptScore W1635738393C104317684 @default.
- W1635738393 hasConceptScore W1635738393C105580179 @default.
- W1635738393 hasConceptScore W1635738393C134018914 @default.
- W1635738393 hasConceptScore W1635738393C150194340 @default.
- W1635738393 hasConceptScore W1635738393C165864922 @default.
- W1635738393 hasConceptScore W1635738393C202751555 @default.
- W1635738393 hasConceptScore W1635738393C2779064019 @default.
- W1635738393 hasConceptScore W1635738393C28483552 @default.
- W1635738393 hasConceptScore W1635738393C55493867 @default.
- W1635738393 hasConceptScore W1635738393C56191518 @default.
- W1635738393 hasConceptScore W1635738393C71315377 @default.
- W1635738393 hasConceptScore W1635738393C86803240 @default.
- W1635738393 hasIssue "7" @default.
- W1635738393 hasLocation W16357383931 @default.
- W1635738393 hasOpenAccess W1635738393 @default.
- W1635738393 hasPrimaryLocation W16357383931 @default.
- W1635738393 hasRelatedWork W2033209790 @default.
- W1635738393 hasRelatedWork W2036917468 @default.
- W1635738393 hasRelatedWork W2074425511 @default.
- W1635738393 hasRelatedWork W2080367469 @default.
- W1635738393 hasRelatedWork W2152306407 @default.
- W1635738393 hasRelatedWork W2187964687 @default.
- W1635738393 hasRelatedWork W2330497441 @default.
- W1635738393 hasRelatedWork W35269982 @default.
- W1635738393 hasRelatedWork W41472429 @default.
- W1635738393 hasRelatedWork W4241810725 @default.
- W1635738393 hasVolume "253" @default.
- W1635738393 isParatext "false" @default.
- W1635738393 isRetracted "false" @default.
- W1635738393 magId "1635738393" @default.
- W1635738393 workType "article" @default.