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- W163574927 abstract "ABSTRACT A 4 to 6 fold increase in rabbit synovial hydraulic permeability following the specific removal of synovial hyaluronan with Streptomyces hyaluronate lyase was investigated ultrastructurally using transmission electron microscopy. Bundles of type I/III/V fibrils appear to undergo an internal collapse following enzyme treatment in vivo with a reduction in interfibrillar volume fraction from 57.13 + 9.09 in the control tissue to 42.69 ± 5.87 in the enzyme treated tissue (n=100 bundles each, p=7.13 × 10-9). Removal of hyaluronan appears to cause matrix disorganisation and collapse, contributing to the permeability increase previously observed." @default.
- W163574927 created "2016-06-24" @default.
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- W163574927 date "2002-01-01" @default.
- W163574927 modified "2023-09-26" @default.
- W163574927 title "ULTRASTRUCTURAL EVIDENCE FOR EXTRACELLULAR MATRIX DISORGANISATION FOLLOWING SPECIFIC REMOVAL OF HYALURONAN FROM SYNOVIUM" @default.
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- W163574927 doi "https://doi.org/10.1533/9781845693121.337" @default.
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