FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1635927011> ?p ?o ?g. }

• W1635927011 endingPage "233" @default.
• W1635927011 startingPage "221" @default.
• W1635927011 abstract "// Consalvo Petti 1 , Gabriele Picco 1,2 , Maria Luisa Martelli 1 , Elena Trisolini 2,3 , Enrico Bucci 4 , Timothy Perera 5 , Claudio Isella 1,2 and Enzo Medico 1,2 1 Candiolo Cancer Institute - FPO IRCCS, Italy 2 Department of Oncology, University of Torino, Italy 3 Istituto Nazionale Biostrutture e Biosistemi, Roma, Italy 4 Biodigitalvalley Srl, Pont Saint Martin, Aosta, Italy 5 Janssen Research and Development, Oncology Discovery, Beerse, Belgium Correspondence: Enzo Medico, email: // Keywords : drug resistance; RAF1; BRAF; MET; gastric cancer Received : October 12, 2014 Accepted : November 14, 2014 Published : November 15, 2014 Abstract Constitutively active receptor tyrosine kinases (RTKs) are known oncogenic drivers and provide valuable therapeutic targets in many cancer types. However, clinical efficacy of RTK inhibitors is limited by intrinsic and acquired resistance. To identify genes conferring resistance to inhibition of the MET RTK, we conducted a forward genetics screen in the GTL-16 gastric cancer cell line, carrying MET amplification and exquisitely sensitive to MET inhibition. Cells were transduced with three different retroviral cDNA expression libraries and selected for growth in the presence of the MET inhibitor PHA-665752. Selected cells displayed robust and reproducible enrichment of library-derived cDNAs encoding truncated forms of RAF1 and BRAF proteins, whose silencing reversed the resistant phenotype. Transduction of naïve GTL-16 cells with truncated, but not full length, RAF1 and BRAF conferred in vitro and in vivo resistance to MET inhibitors, which could be reversed by MEK inhibition. Induction of resistance by truncated RAFs was confirmed in other MET-addicted cell lines, and further extended to EGFR-addicted cells. These data show that truncated RAF1 and BRAF proteins, recently described as products of genomic rearrangements in gastric cancer and other malignancies, have the ability to render neoplastic cells resistant to RTK-targeted therapy." @default.
• W1635927011 created "2016-06-24" @default.
• W1635927011 creator A5009105578 @default.
• W1635927011 creator A5010242514 @default.
• W1635927011 creator A5040419312 @default.
• W1635927011 creator A5049326120 @default.
• W1635927011 creator A5056194390 @default.
• W1635927011 creator A5056598174 @default.
• W1635927011 creator A5064827031 @default.
• W1635927011 creator A5080555744 @default.
• W1635927011 date "2014-11-15" @default.
• W1635927011 modified "2023-09-23" @default.
• W1635927011 title "Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells" @default.
• W1635927011 cites W1556788203 @default.
• W1635927011 cites W1775658852 @default.
• W1635927011 cites W1966686696 @default.
• W1635927011 cites W1972301614 @default.
• W1635927011 cites W1977044507 @default.
• W1635927011 cites W1985562847 @default.
• W1635927011 cites W1990089179 @default.
• W1635927011 cites W1991620699 @default.
• W1635927011 cites W1996372785 @default.
• W1635927011 cites W1999172536 @default.
• W1635927011 cites W2004295816 @default.
• W1635927011 cites W2013678879 @default.
• W1635927011 cites W2017090190 @default.
• W1635927011 cites W2028415754 @default.
• W1635927011 cites W2029575024 @default.
• W1635927011 cites W2030440427 @default.
• W1635927011 cites W2042666390 @default.
• W1635927011 cites W2043023585 @default.
• W1635927011 cites W2043058822 @default.
• W1635927011 cites W2055191970 @default.
• W1635927011 cites W2055560959 @default.
• W1635927011 cites W2058142370 @default.
• W1635927011 cites W2062109911 @default.
• W1635927011 cites W2062110561 @default.
• W1635927011 cites W2065538031 @default.
• W1635927011 cites W2067414313 @default.
• W1635927011 cites W2068310793 @default.
• W1635927011 cites W2072996947 @default.
• W1635927011 cites W2074591493 @default.
• W1635927011 cites W2096165693 @default.
• W1635927011 cites W2096844786 @default.
• W1635927011 cites W2102646127 @default.
• W1635927011 cites W2108861561 @default.
• W1635927011 cites W2123326378 @default.
• W1635927011 cites W2123551753 @default.
• W1635927011 cites W2124138281 @default.
• W1635927011 cites W2125703895 @default.
• W1635927011 cites W2129837161 @default.
• W1635927011 cites W2137390717 @default.
• W1635927011 cites W2140932756 @default.
• W1635927011 cites W2151183547 @default.
• W1635927011 cites W2164144078 @default.
• W1635927011 cites W2166245580 @default.
• W1635927011 cites W2169438753 @default.
• W1635927011 cites W2217741105 @default.
• W1635927011 cites W2236745316 @default.
• W1635927011 cites W2400986674 @default.
• W1635927011 cites W4237747603 @default.
• W1635927011 doi "https://doi.org/10.18632/oncotarget.2771" @default.
• W1635927011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4381590" @default.
• W1635927011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25473895" @default.
• W1635927011 hasPublicationYear "2014" @default.
• W1635927011 type Work @default.
• W1635927011 sameAs 1635927011 @default.
• W1635927011 citedByCount "15" @default.
• W1635927011 countsByYear W16359270112015 @default.
• W1635927011 countsByYear W16359270112016 @default.
• W1635927011 countsByYear W16359270112017 @default.
• W1635927011 countsByYear W16359270112018 @default.
• W1635927011 countsByYear W16359270112020 @default.
• W1635927011 countsByYear W16359270112021 @default.
• W1635927011 countsByYear W16359270112022 @default.
• W1635927011 crossrefType "journal-article" @default.
• W1635927011 hasAuthorship W1635927011A5009105578 @default.
• W1635927011 hasAuthorship W1635927011A5010242514 @default.
• W1635927011 hasAuthorship W1635927011A5040419312 @default.
• W1635927011 hasAuthorship W1635927011A5049326120 @default.
• W1635927011 hasAuthorship W1635927011A5056194390 @default.
• W1635927011 hasAuthorship W1635927011A5056598174 @default.
• W1635927011 hasAuthorship W1635927011A5064827031 @default.
• W1635927011 hasAuthorship W1635927011A5080555744 @default.
• W1635927011 hasBestOaLocation W16359270111 @default.
• W1635927011 hasConcept C101544691 @default.
• W1635927011 hasConcept C104317684 @default.
• W1635927011 hasConcept C119056186 @default.
• W1635927011 hasConcept C121608353 @default.
• W1635927011 hasConcept C126322002 @default.
• W1635927011 hasConcept C153911025 @default.
• W1635927011 hasConcept C170493617 @default.
• W1635927011 hasConcept C184235292 @default.
• W1635927011 hasConcept C2776996007 @default.
• W1635927011 hasConcept C2779707156 @default.
• W1635927011 hasConcept C2780467284 @default.
• W1635927011 hasConcept C502942594 @default.
• W1635927011 hasConcept C54355233 @default.

• next