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- W163599729 abstract "Certain thiols such as β-mercaptoethylamine, β-mercaptoethanol, ethanethiol and dithiothreitol inhibit cholesterol synthesis from mevalonic acid (MVA) in rat liver homogenates and cause accumulation of a mixture of lanosta-8,24-dien-3β-ol (lanosterol) and lanost-8-en-3β-01 (Δ8-lanosterol). Cysteine and glutathione inhibit cholesterol synthesis without accumulation of lanosterol and Δ8-lanosterol. Since it has been proposed that the demethylation of lanosterol involves hydroxylation of the methyl group this process must differ from certain P450-dependent mixed function oxidases which are stimulated by similar concentrations of β-mercaptoethylamine." @default.
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- W163599729 date "1970-08-01" @default.
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- W163599729 title "The effects of thiols on cholesterol synthesis by rat liver in vitro" @default.
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- W163599729 doi "https://doi.org/10.1016/0006-291x(70)90933-2" @default.
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