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- W1636126868 abstract "textabstractTransplantation of living tissues is not a new concept. Greekmythology presents us with the Chimera in which a goat's body, alion's head and a dragon's tail are joined to form a terrifying monster.Ancient Indian surgeons made use of local skin flaps for rhinoplasty,an art which has been practiced in Italy as early as the fifteenthcentury.Various transplantation experiments were performed by JohnHunter in the eighteenth century. However, a systematic approach tothe study of transplantation biology has only been started during thepresent century when technical progress in the field of surgery(Carrel and Guthrie 1905, 1906; Carrel 1908) made it possible totransplant a large variety of tissues and organs.Unfortunately, surgical problems are not the only obstacles tosuccessful transplantation. lt has been known for a long time thattissue transplants in which the donor is also the recipient (autografts)or transplants between animals of the same inbred strain (isografts)will survive. Without complications this also applies to grafts betweenidentical twins. On the other hand, transplants between two randomlychosen individuals of the same species called homografts or allografts,behave like autografts for a few days only, after which progressivedamage occurs, leading to loss of function and destruction ofthe graft. This process, called rejection, is usually complete within afew weeks following transplantation and is invariably accompaniedby infiltration with inflammatory cells, predominantly of the mononucleartype. In transplants exchanged between members of differentspecies (heterografts, syn. xenografts), a much more violent andrapid rejection may take place." @default.
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- W1636126868 date "1970-11-25" @default.
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- W1636126868 title "The effect of immunosuppression on function of kidney allografts in the rat" @default.
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