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- W163634367 abstract "Cells and tissues transplanted into the adult brain or spinal cord have been shown to exert functional effects on the behavior of host animals in a variety of model systems, as well as in patients with neurodegenerative disease. Nevertheless, the observation of functional recovery does not necessarily imply structural repair. Transplanted cells could theoretically influence host behavior by a variety of different mechanisms of lesser or greater specificity, including nonspecific effects of surgical damage, delivery of pharmacological or trophic molecules, glial support, stimulation of host plasticity, as well as specific neuronal and glial cell replacement, reformation of axonal connections, and circuit repair. Not all grafts work by the same mechanism, and examples of each have been observed in different model systems. Each target system therefore requires separate analysis of the different levels of interaction in order to design the most effective and efficient cell replacement strategies for the particular disorder or symptoms of concern." @default.
- W163634367 created "2016-06-24" @default.
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- W163634367 date "2009-01-01" @default.
- W163634367 modified "2023-09-25" @default.
- W163634367 title "Cell Replacement Therapy: Mechanisms of Functional Recovery" @default.
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- W163634367 doi "https://doi.org/10.1016/b978-008045046-9.00007-3" @default.
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