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- W1636375730 abstract "Results: Co-administration of ART with amodiaquine (AMQ), mefloquine (MFQ) and sulphadoxine/pyremethamine (SP) respectively, on the 4th day of the studies increased the mean plasma concentration of AST to 80.70%, 108.0% and 75.0% against 59% for ART alone; ALT increased to 104%, 33.0% and 43.30% against 25.05% for ART alone; total bilirubin (TBIL) increased to 80.0%, 78.88% and 98.91% against 17.6% for ART alone. The co-administration and post-administration of ART and the ACTs with 900mg and 1800mg daily dose of PL respectively reduced the levels of the AST, ALT and BIL by 65.0% and 97.0% of the increased values respectively on 4th day. Discussion: The results suggest that ART as a monotherapeutic agent has injurious effect on the liver, and this effect is aggravated when ART is used in ACTs, however, the co-administration with phospholipids cushions the adverse effects." @default.
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- W1636375730 date "2013-03-31" @default.
- W1636375730 modified "2023-09-26" @default.
- W1636375730 title "Effect of some Artemisinin and Combination Therapy Regimens with and without Concomitant Administration of Phospholipids on the Levels of Plasma Aminotransferases and Bilirubin in Nigerian Male Subjects" @default.
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