FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1636854345> ?p ?o ?g. }

• W1636854345 endingPage "e0132617" @default.
• W1636854345 startingPage "e0132617" @default.
• W1636854345 abstract "Regulatory T cells (Tregs) are physiologically designed to prevent autoimmune disease and maintain self-tolerance. In tumour microenvironments, their presence is related to a poor prognosis, and they influence the therapeutic outcome due to their capacity to suppress the immune response by cell-cell contact and to release immunosuppressive cytokines. In this study, we demonstrate that Treg immunosuppressive activity can be modulated by the cross-linking between the CD45RA expressed by Tregs and the C-type lectin MGL. This specific interaction strongly decreases the im-munosuppressive activity of Tregs, restoring the proliferative capacity of co-cultured T lymphocytes. This effect can be attributed to changes in CD45RA and TCR signalling through the inhibition of Lck and inactivation of Zap-70, an increase in the Foxp3 methylation status and, ultimately, the reduced production of suppressive cytokines. These results indicate a role of MGL as an immunomodulator within the tumour microenvironment interfering with Treg functions, suggesting its possible use in the design of anticancer vaccines." @default.
• W1636854345 created "2016-06-24" @default.
• W1636854345 creator A5013451369 @default.
• W1636854345 creator A5019444838 @default.
• W1636854345 creator A5036375780 @default.
• W1636854345 creator A5067780934 @default.
• W1636854345 creator A5069311489 @default.
• W1636854345 creator A5071855568 @default.
• W1636854345 creator A5076917549 @default.
• W1636854345 creator A5077736286 @default.
• W1636854345 creator A5085420813 @default.
• W1636854345 date "2015-07-06" @default.
• W1636854345 modified "2023-10-02" @default.
• W1636854345 title "The Macrophage Galactose-Type C-Type Lectin (MGL) Modulates Regulatory T Cell Functions" @default.
• W1636854345 cites W1489142574 @default.
• W1636854345 cites W1508663375 @default.
• W1636854345 cites W1560636891 @default.
• W1636854345 cites W1964080141 @default.
• W1636854345 cites W1964144818 @default.
• W1636854345 cites W1966657187 @default.
• W1636854345 cites W1972305772 @default.
• W1636854345 cites W1986644831 @default.
• W1636854345 cites W1989354231 @default.
• W1636854345 cites W2003143820 @default.
• W1636854345 cites W2006065705 @default.
• W1636854345 cites W2007631222 @default.
• W1636854345 cites W2012729754 @default.
• W1636854345 cites W2065289702 @default.
• W1636854345 cites W2073218792 @default.
• W1636854345 cites W2097811455 @default.
• W1636854345 cites W2103170395 @default.
• W1636854345 cites W2104667967 @default.
• W1636854345 cites W2124621398 @default.
• W1636854345 cites W2134656124 @default.
• W1636854345 cites W2148226248 @default.
• W1636854345 cites W2150678612 @default.
• W1636854345 cites W2152624886 @default.
• W1636854345 cites W2161148075 @default.
• W1636854345 cites W2162261192 @default.
• W1636854345 cites W2165198071 @default.
• W1636854345 doi "https://doi.org/10.1371/journal.pone.0132617" @default.
• W1636854345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4493043" @default.
• W1636854345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26147970" @default.
• W1636854345 hasPublicationYear "2015" @default.
• W1636854345 type Work @default.
• W1636854345 sameAs 1636854345 @default.
• W1636854345 citedByCount "18" @default.
• W1636854345 countsByYear W16368543452015 @default.
• W1636854345 countsByYear W16368543452016 @default.
• W1636854345 countsByYear W16368543452017 @default.
• W1636854345 countsByYear W16368543452018 @default.
• W1636854345 countsByYear W16368543452019 @default.
• W1636854345 countsByYear W16368543452020 @default.
• W1636854345 countsByYear W16368543452021 @default.
• W1636854345 countsByYear W16368543452022 @default.
• W1636854345 countsByYear W16368543452023 @default.
• W1636854345 crossrefType "journal-article" @default.
• W1636854345 hasAuthorship W1636854345A5013451369 @default.
• W1636854345 hasAuthorship W1636854345A5019444838 @default.
• W1636854345 hasAuthorship W1636854345A5036375780 @default.
• W1636854345 hasAuthorship W1636854345A5067780934 @default.
• W1636854345 hasAuthorship W1636854345A5069311489 @default.
• W1636854345 hasAuthorship W1636854345A5071855568 @default.
• W1636854345 hasAuthorship W1636854345A5076917549 @default.
• W1636854345 hasAuthorship W1636854345A5077736286 @default.
• W1636854345 hasAuthorship W1636854345A5085420813 @default.
• W1636854345 hasBestOaLocation W16368543451 @default.
• W1636854345 hasConcept C164027704 @default.
• W1636854345 hasConcept C179464577 @default.
• W1636854345 hasConcept C185592680 @default.
• W1636854345 hasConcept C203014093 @default.
• W1636854345 hasConcept C2776090121 @default.
• W1636854345 hasConcept C2776914184 @default.
• W1636854345 hasConcept C2777702733 @default.
• W1636854345 hasConcept C2778296632 @default.
• W1636854345 hasConcept C2779727006 @default.
• W1636854345 hasConcept C2780758401 @default.
• W1636854345 hasConcept C502942594 @default.
• W1636854345 hasConcept C79484868 @default.
• W1636854345 hasConcept C86803240 @default.
• W1636854345 hasConcept C8891405 @default.
• W1636854345 hasConcept C95444343 @default.
• W1636854345 hasConceptScore W1636854345C164027704 @default.
• W1636854345 hasConceptScore W1636854345C179464577 @default.
• W1636854345 hasConceptScore W1636854345C185592680 @default.
• W1636854345 hasConceptScore W1636854345C203014093 @default.
• W1636854345 hasConceptScore W1636854345C2776090121 @default.
• W1636854345 hasConceptScore W1636854345C2776914184 @default.
• W1636854345 hasConceptScore W1636854345C2777702733 @default.
• W1636854345 hasConceptScore W1636854345C2778296632 @default.
• W1636854345 hasConceptScore W1636854345C2779727006 @default.
• W1636854345 hasConceptScore W1636854345C2780758401 @default.
• W1636854345 hasConceptScore W1636854345C502942594 @default.
• W1636854345 hasConceptScore W1636854345C79484868 @default.
• W1636854345 hasConceptScore W1636854345C86803240 @default.
• W1636854345 hasConceptScore W1636854345C8891405 @default.
• W1636854345 hasConceptScore W1636854345C95444343 @default.
• W1636854345 hasIssue "7" @default.

• next