Matches in SemOpenAlex for { <https://semopenalex.org/work/W1637114906> ?p ?o ?g. }
- W1637114906 endingPage "115" @default.
- W1637114906 startingPage "106" @default.
- W1637114906 abstract "Degenerative lung diseases such as chronic obstructive pulmonary disease (COPD) are common with huge worldwide morbidity. Anti-inflammatory drug development strategies have proved disappointing and current treatment is aimed at symptomatic relief. Only lung transplantation with all its attendant difficulties offers hope of cure and the outlook for affected patients is bleak. Lung regeneration therapies aim to reverse the structural and functional deficits in COPD either by delivery of exogenous lung cells to replace lost tissue, delivery of exogenous stem cells to induce a local paracrine effect probably through an anti-inflammatory action or by the administration of small molecules to stimulate the endogenous regenerative ability of lung cells. In animal models of emphysema and disrupted alveolar development each of these strategies has shown some success but there are potential tumour-inducing dangers with a cellular approach. Small molecules such as all-trans retinoic acid have been successful in animal models although the mechanism is not completely understood. There are currently two Pharma-sponsored trials in progress concerning patients with COPD, one of a specific retinoic acid receptor gamma agonist and another using mesenchymal stem cells. LINKED ARTICLES This article is part of a themed issue on Respiratory Pharmacology. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2011.163.issue-1" @default.
- W1637114906 created "2016-06-24" @default.
- W1637114906 creator A5018907985 @default.
- W1637114906 creator A5022416667 @default.
- W1637114906 date "2011-04-06" @default.
- W1637114906 modified "2023-09-25" @default.
- W1637114906 title "Is a regenerative approach viable for the treatment of COPD?" @default.
- W1637114906 cites W1504736885 @default.
- W1637114906 cites W1589927530 @default.
- W1637114906 cites W1747167238 @default.
- W1637114906 cites W1878504844 @default.
- W1637114906 cites W1918758867 @default.
- W1637114906 cites W1939202796 @default.
- W1637114906 cites W195910843 @default.
- W1637114906 cites W1965459362 @default.
- W1637114906 cites W1977144038 @default.
- W1637114906 cites W1977277876 @default.
- W1637114906 cites W1978957262 @default.
- W1637114906 cites W1979043688 @default.
- W1637114906 cites W1980419256 @default.
- W1637114906 cites W1981654793 @default.
- W1637114906 cites W1985002063 @default.
- W1637114906 cites W1993359142 @default.
- W1637114906 cites W1996337101 @default.
- W1637114906 cites W1996813404 @default.
- W1637114906 cites W1997793134 @default.
- W1637114906 cites W1999226863 @default.
- W1637114906 cites W2001675896 @default.
- W1637114906 cites W2002218087 @default.
- W1637114906 cites W2002726093 @default.
- W1637114906 cites W2003996125 @default.
- W1637114906 cites W2004838385 @default.
- W1637114906 cites W2005028693 @default.
- W1637114906 cites W2007927680 @default.
- W1637114906 cites W2008188840 @default.
- W1637114906 cites W2011333762 @default.
- W1637114906 cites W2013108368 @default.
- W1637114906 cites W2017461303 @default.
- W1637114906 cites W2018599317 @default.
- W1637114906 cites W2024925152 @default.
- W1637114906 cites W2024962699 @default.
- W1637114906 cites W2026452626 @default.
- W1637114906 cites W2027812171 @default.
- W1637114906 cites W2032482949 @default.
- W1637114906 cites W2035435664 @default.
- W1637114906 cites W2035657747 @default.
- W1637114906 cites W2036960796 @default.
- W1637114906 cites W2040111843 @default.
- W1637114906 cites W2043865547 @default.
- W1637114906 cites W2044782007 @default.
- W1637114906 cites W2048367533 @default.
- W1637114906 cites W2051806959 @default.
- W1637114906 cites W2052492381 @default.
- W1637114906 cites W2055670245 @default.
- W1637114906 cites W2056854810 @default.
- W1637114906 cites W2056920235 @default.
- W1637114906 cites W2060573440 @default.
- W1637114906 cites W2066029878 @default.
- W1637114906 cites W2067920235 @default.
- W1637114906 cites W2071142855 @default.
- W1637114906 cites W2074495000 @default.
- W1637114906 cites W2079390617 @default.
- W1637114906 cites W2080651474 @default.
- W1637114906 cites W2085182473 @default.
- W1637114906 cites W2091932817 @default.
- W1637114906 cites W2098597036 @default.
- W1637114906 cites W2105161501 @default.
- W1637114906 cites W2105250564 @default.
- W1637114906 cites W2105902643 @default.
- W1637114906 cites W2108355102 @default.
- W1637114906 cites W2108626209 @default.
- W1637114906 cites W2112499266 @default.
- W1637114906 cites W2114066412 @default.
- W1637114906 cites W2116141140 @default.
- W1637114906 cites W2116397695 @default.
- W1637114906 cites W2117248052 @default.
- W1637114906 cites W2119835285 @default.
- W1637114906 cites W2125987139 @default.
- W1637114906 cites W2126134953 @default.
- W1637114906 cites W2126780067 @default.
- W1637114906 cites W2127327473 @default.
- W1637114906 cites W2128073106 @default.
- W1637114906 cites W2128698379 @default.
- W1637114906 cites W2130460706 @default.
- W1637114906 cites W2133745182 @default.
- W1637114906 cites W2133907795 @default.
- W1637114906 cites W2135490386 @default.
- W1637114906 cites W2138690739 @default.
- W1637114906 cites W2139373056 @default.
- W1637114906 cites W2139697647 @default.
- W1637114906 cites W2141041714 @default.
- W1637114906 cites W2144473231 @default.
- W1637114906 cites W2147156629 @default.
- W1637114906 cites W2147488335 @default.
- W1637114906 cites W2150103989 @default.
- W1637114906 cites W2152515242 @default.
- W1637114906 cites W2153999097 @default.
- W1637114906 cites W2157341735 @default.