FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W163713508> ?p ?o ?g. }

• W163713508 abstract "In 2008, the European Cooperative Acute Stroke Study-3 (ECASS-3) demonstrated that intravenous-tissue plasminogen activator could be safely administered for acute stroke patients presenting between 3 and 4.5 hours from symptom onset. Recently, the Food and Drug Administration rejected expansion of this time window in the United States. We sought to determine how many fewer patients would be treated by maintaining this restricted time window.We reviewed charts from patients who received intravenous thrombolysis at the University of Alabama at Birmingham between January 2009 and December 2011. Patients were divided into two groups (treated within 3 hours of onset, treated between 3 and 4.5 hours from onset). Demographics, stroke severity and protocol deviations according to the ECASS-3 trial were collected. Our safety measures were any hemorrhagic transformation, symptomatic intracerebral hemorrhage and systemic hemorrhage.Two hundred and twelve patients were identified, of whom 192 were included in our analysis. A total of 36 patients (19%) were treated between 3 and 4.5 hours. No statistical differences were seen between age (p=0.633), gender (p=0.677), race (p=0.207) or admission stroke severity (p=0.737). Protocol deviations from the ECASS-3 criteria were found in 20 patients (56%). These were primarily age > 80 and aggressive blood pressure management. Despite these deviations, we did not see significant increases in the rates of adverse events in patients treated in the extended time window.Our data are consistent with previously reported international data that IV thrombolysis can safely be used up to 4.5 hours from symptom onset. Restricting the time window to 3 hours would have resulted in almost one-fifth fewer patients treated at our center." @default.
• W163713508 created "2016-06-24" @default.
• W163713508 creator A5014560123 @default.
• W163713508 creator A5027449955 @default.
• W163713508 creator A5035161117 @default.
• W163713508 creator A5060351508 @default.
• W163713508 creator A5062255303 @default.
• W163713508 creator A5065673197 @default.
• W163713508 creator A5074277589 @default.
• W163713508 creator A5076074302 @default.
• W163713508 creator A5076989813 @default.
• W163713508 creator A5080030721 @default.
• W163713508 creator A5080088522 @default.
• W163713508 date "2013-09-13" @default.
• W163713508 modified "2023-09-24" @default.
• W163713508 title "The Potential Impact of Maintaining a 3-Hour IV Thrombolysis Window: How Many More Patients can we Safely Treat?" @default.
• W163713508 cites W119839859 @default.
• W163713508 cites W1966916869 @default.
• W163713508 cites W1977351197 @default.
• W163713508 cites W1977858475 @default.
• W163713508 cites W1987803507 @default.
• W163713508 cites W2004032944 @default.
• W163713508 cites W2009613222 @default.
• W163713508 cites W2029445248 @default.
• W163713508 cites W2036736823 @default.
• W163713508 cites W2042368174 @default.
• W163713508 cites W2054290708 @default.
• W163713508 cites W2063544001 @default.
• W163713508 cites W2083265787 @default.
• W163713508 cites W2084564305 @default.
• W163713508 cites W2098032054 @default.
• W163713508 cites W2102828922 @default.
• W163713508 cites W2109783545 @default.
• W163713508 cites W2111519145 @default.
• W163713508 cites W2127272421 @default.
• W163713508 cites W2134155944 @default.
• W163713508 cites W2138600212 @default.
• W163713508 cites W2141132646 @default.
• W163713508 cites W2154350726 @default.
• W163713508 cites W2159233098 @default.
• W163713508 cites W2164960480 @default.
• W163713508 cites W2166945097 @default.
• W163713508 cites W2292308933 @default.
• W163713508 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3901990" @default.
• W163713508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24471140" @default.
• W163713508 hasPublicationYear "2013" @default.
• W163713508 type Work @default.
• W163713508 sameAs 163713508 @default.
• W163713508 citedByCount "5" @default.
• W163713508 countsByYear W1637135082015 @default.
• W163713508 countsByYear W1637135082017 @default.
• W163713508 countsByYear W1637135082020 @default.
• W163713508 countsByYear W1637135082022 @default.
• W163713508 crossrefType "journal-article" @default.
• W163713508 hasAuthorship W163713508A5014560123 @default.
• W163713508 hasAuthorship W163713508A5027449955 @default.
• W163713508 hasAuthorship W163713508A5035161117 @default.
• W163713508 hasAuthorship W163713508A5060351508 @default.
• W163713508 hasAuthorship W163713508A5062255303 @default.
• W163713508 hasAuthorship W163713508A5065673197 @default.
• W163713508 hasAuthorship W163713508A5074277589 @default.
• W163713508 hasAuthorship W163713508A5076074302 @default.
• W163713508 hasAuthorship W163713508A5076989813 @default.
• W163713508 hasAuthorship W163713508A5080030721 @default.
• W163713508 hasAuthorship W163713508A5080088522 @default.
• W163713508 hasConcept C126322002 @default.
• W163713508 hasConcept C127413603 @default.
• W163713508 hasConcept C141071460 @default.
• W163713508 hasConcept C144024400 @default.
• W163713508 hasConcept C149923435 @default.
• W163713508 hasConcept C194828623 @default.
• W163713508 hasConcept C197934379 @default.
• W163713508 hasConcept C2776572282 @default.
• W163713508 hasConcept C2777094939 @default.
• W163713508 hasConcept C2777736543 @default.
• W163713508 hasConcept C2779581417 @default.
• W163713508 hasConcept C2780084366 @default.
• W163713508 hasConcept C2780645631 @default.
• W163713508 hasConcept C3020166492 @default.
• W163713508 hasConcept C42219234 @default.
• W163713508 hasConcept C500558357 @default.
• W163713508 hasConcept C71924100 @default.
• W163713508 hasConcept C78519656 @default.
• W163713508 hasConceptScore W163713508C126322002 @default.
• W163713508 hasConceptScore W163713508C127413603 @default.
• W163713508 hasConceptScore W163713508C141071460 @default.
• W163713508 hasConceptScore W163713508C144024400 @default.
• W163713508 hasConceptScore W163713508C149923435 @default.
• W163713508 hasConceptScore W163713508C194828623 @default.
• W163713508 hasConceptScore W163713508C197934379 @default.
• W163713508 hasConceptScore W163713508C2776572282 @default.
• W163713508 hasConceptScore W163713508C2777094939 @default.
• W163713508 hasConceptScore W163713508C2777736543 @default.
• W163713508 hasConceptScore W163713508C2779581417 @default.
• W163713508 hasConceptScore W163713508C2780084366 @default.
• W163713508 hasConceptScore W163713508C2780645631 @default.
• W163713508 hasConceptScore W163713508C3020166492 @default.
• W163713508 hasConceptScore W163713508C42219234 @default.
• W163713508 hasConceptScore W163713508C500558357 @default.
• W163713508 hasConceptScore W163713508C71924100 @default.

• next