FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1637321639> ?p ?o ?g. }

• W1637321639 endingPage "9560" @default.
• W1637321639 startingPage "9549" @default.
• W1637321639 abstract "α-Synuclein mutations have been identified in certain families with Parkinson's disease (PD), and α-synuclein is a major component of Lewy bodies. Other genetic data indicate that the ubiquitin-dependent proteolytic system is involved in PD pathogenesis. We have generated stable PC12 cell lines expressing wild-type or A53T mutant human α-synuclein. Lines expressing mutant but not wild-type α-synuclein show: (1) disruption of the ubiquitin-dependent proteolytic system, manifested by small cytoplasmic ubiquitinated aggregates and by an increase in polyubiquitinated proteins; (2) enhanced baseline nonapoptotic death; (3) marked accumulation of autophagic–vesicular structures; (4) impairment of lysosomal hydrolysis and proteasomal function; and (5) loss of catecholamine-secreting dense core granules and an absence of depolarization-induced dopamine release. Such findings raise the possibility that the primary abnormality in these cells may involve one or more deficits in the lysosomal and/or proteasomal degradation pathways, which in turn lead to loss of dopaminergic capacity and, ultimately, to death. These cells may serve as a model to study the effects of aberrant α-synuclein on dopaminergic cell function and survival." @default.
• W1637321639 created "2016-06-24" @default.
• W1637321639 creator A5026787858 @default.
• W1637321639 creator A5028502903 @default.
• W1637321639 creator A5050331720 @default.
• W1637321639 creator A5089947731 @default.
• W1637321639 creator A5091849508 @default.
• W1637321639 date "2001-12-15" @default.
• W1637321639 modified "2023-10-18" @default.
• W1637321639 title "Expression of A53T Mutant But Not Wild-Type α-Synuclein in PC12 Cells Induces Alterations of the Ubiquitin-Dependent Degradation System, Loss of Dopamine Release, and Autophagic Cell Death" @default.
• W1637321639 cites W135471365 @default.
• W1637321639 cites W1494109356 @default.
• W1637321639 cites W1516811504 @default.
• W1637321639 cites W1527671059 @default.
• W1637321639 cites W1530609782 @default.
• W1637321639 cites W1550876205 @default.
• W1637321639 cites W1557235501 @default.
• W1637321639 cites W1565639403 @default.
• W1637321639 cites W1572679174 @default.
• W1637321639 cites W1603686013 @default.
• W1637321639 cites W1618846043 @default.
• W1637321639 cites W163282691 @default.
• W1637321639 cites W1824123796 @default.
• W1637321639 cites W1877873625 @default.
• W1637321639 cites W1940885739 @default.
• W1637321639 cites W1962595227 @default.
• W1637321639 cites W1966326184 @default.
• W1637321639 cites W1970587959 @default.
• W1637321639 cites W1971236779 @default.
• W1637321639 cites W1972522869 @default.
• W1637321639 cites W1975904615 @default.
• W1637321639 cites W1976148085 @default.
• W1637321639 cites W1986188355 @default.
• W1637321639 cites W1986625112 @default.
• W1637321639 cites W1987049871 @default.
• W1637321639 cites W1989149919 @default.
• W1637321639 cites W1991289203 @default.
• W1637321639 cites W1996222810 @default.
• W1637321639 cites W1998938906 @default.
• W1637321639 cites W2000039904 @default.
• W1637321639 cites W2001407922 @default.
• W1637321639 cites W2003852184 @default.
• W1637321639 cites W2008748100 @default.
• W1637321639 cites W2011543201 @default.
• W1637321639 cites W2012337697 @default.
• W1637321639 cites W2025922492 @default.
• W1637321639 cites W2027649342 @default.
• W1637321639 cites W2030748454 @default.
• W1637321639 cites W2034587793 @default.
• W1637321639 cites W2035232504 @default.
• W1637321639 cites W2039568629 @default.
• W1637321639 cites W2039824115 @default.
• W1637321639 cites W2049104084 @default.
• W1637321639 cites W2050786534 @default.
• W1637321639 cites W2052714679 @default.
• W1637321639 cites W2052974495 @default.
• W1637321639 cites W2056769035 @default.
• W1637321639 cites W2059737503 @default.
• W1637321639 cites W2061489149 @default.
• W1637321639 cites W2064444660 @default.
• W1637321639 cites W2065376500 @default.
• W1637321639 cites W2067340670 @default.
• W1637321639 cites W2075927534 @default.
• W1637321639 cites W2076344205 @default.
• W1637321639 cites W2089865526 @default.
• W1637321639 cites W2090698021 @default.
• W1637321639 cites W2091265794 @default.
• W1637321639 cites W2094297139 @default.
• W1637321639 cites W2096885631 @default.
• W1637321639 cites W2098553992 @default.
• W1637321639 cites W2104912043 @default.
• W1637321639 cites W2112775462 @default.
• W1637321639 cites W2117184453 @default.
• W1637321639 cites W2119092360 @default.
• W1637321639 cites W2119361990 @default.
• W1637321639 cites W2142780460 @default.
• W1637321639 cites W2150656456 @default.
• W1637321639 cites W2163012098 @default.
• W1637321639 cites W2164398262 @default.
• W1637321639 cites W2168155492 @default.
• W1637321639 cites W2339865699 @default.
• W1637321639 cites W2415221899 @default.
• W1637321639 cites W4295689620 @default.
• W1637321639 cites W4312960592 @default.
• W1637321639 cites W94318861 @default.
• W1637321639 doi "https://doi.org/10.1523/jneurosci.21-24-09549.2001" @default.
• W1637321639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6763041" @default.
• W1637321639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11739566" @default.
• W1637321639 hasPublicationYear "2001" @default.
• W1637321639 type Work @default.
• W1637321639 sameAs 1637321639 @default.
• W1637321639 citedByCount "541" @default.
• W1637321639 countsByYear W16373216392012 @default.
• W1637321639 countsByYear W16373216392013 @default.
• W1637321639 countsByYear W16373216392014 @default.
• W1637321639 countsByYear W16373216392015 @default.
• W1637321639 countsByYear W16373216392016 @default.
• W1637321639 countsByYear W16373216392017 @default.

• next