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- W1637475772 abstract "The activated NF- κ B signaling pathway plays an important role in pathogenesis of primary Sjögren’s syndrome (pSS). The inhibitor of κ B (I κ B) kinase (IKK) family such as IKK α , IKK β , IKK γ , and IKK ε , is required for this signaling. Our aim was to investigate the role of IKK α / β / γ / ε in patients with untreated pSS. In minor salivary glands from pSS patients, phosphorylated IKK ε (pIKK ε ), pI κ B α , and pNF- κ B p65 (p-p65) were highly expressed in ductal epithelium and infiltrating mononuclear cells by immunohistochemistry, compared to healthy individuals. pIKK α / β and pIKK γ were both negative. And pIKK ε positively related to expression of p-p65. Furthermore, pIKK ε and p-p65 expression significantly correlated with biopsy focus score and overall disease activity. Meanwhile, in peripheral blood mononuclear cells from pSS patients, pIKK ε , total IKK ε , pIKK α / β , and p-p65 were significantly increased by western blot, compared to healthy controls. However, there was no difference in IKK γ and I κ B α between pSS patients and healthy individuals. These results demonstrated an abnormality of IKK ε , I κ B α , and NF- κ B in pSS, suggesting a potential target of treatment for pSS based on the downregulation of IKK ε expression and deregulation of NF- κ B pathway." @default.
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- W1637475772 date "2015-01-01" @default.
- W1637475772 modified "2023-10-16" @default.
- W1637475772 title "Local and Systemic IKK<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mo mathvariant=bold>ε</mml:mo></mml:mrow></mml:math>and NF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mo mathvariant=bold>κ</mml:mo></mml:mrow></mml:math>B Signaling Associated with Sjögren’s Syndrome Immunopathogenesis" @default.
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- W1637475772 doi "https://doi.org/10.1155/2015/534648" @default.
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