FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1637778269> ?p ?o ?g. }

• W1637778269 endingPage "8" @default.
• W1637778269 startingPage "1" @default.
• W1637778269 abstract "Buchang NaoXinTong capsule (NXT) is a Chinese Materia Medica standardized product extracted from 16 Chinese traditional medical herbs and widely used for treatment of patients with cerebrovascular and cardiovascular diseases in China. Formation of microaneurysms plays an important role in the development of diabetic retinopathy. In this study, we investigated if NXT can protect diabetic mice against the development of diabetic retinopathy. The<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>d</mml:mi><mml:mi>b</mml:mi><mml:mo>/</mml:mo><mml:mi>d</mml:mi><mml:mi>b</mml:mi></mml:math>mice (~6 weeks old), a diabetic animal model, were divided into two groups and fed normal chow or plus NXT for 14 weeks. During the treatment, fasting blood glucose levels were monthly determined. After treatment, retinas were collected to determine retinal thickness, accumulation of carbohydrate macromolecules, and caspase-3 (CAS-3) expression. Our results demonstrate that administration of NXT decreased fasting blood glucose levels. Associated with the decreased glucose levels, NXT blocked the diabetes-induced shrink of multiple layers, such as photoreceptor layer and outer nuclear/plexiform layers, in the retina. NXT also inhibited the diabetes-induced expression of CAS-3 protein and mRNA, MMP-2/9 and TNF α mRNA, accumulation of carbohydrate macromolecules, and formation of acellular capillaries in the retina. Taken together, our study shows that NXT can inhibit the development of diabetic retinopathy and suggests a new potential application of NXT in clinic." @default.
• W1637778269 created "2016-06-24" @default.
• W1637778269 creator A5005205790 @default.
• W1637778269 creator A5013125144 @default.
• W1637778269 creator A5018938895 @default.
• W1637778269 creator A5028875731 @default.
• W1637778269 creator A5038840176 @default.
• W1637778269 creator A5044788727 @default.
• W1637778269 creator A5059838901 @default.
• W1637778269 creator A5060454242 @default.
• W1637778269 creator A5079730676 @default.
• W1637778269 creator A5039020375 @default.
• W1637778269 date "2015-01-01" @default.
• W1637778269 modified "2023-10-15" @default.
• W1637778269 title "NaoXinTong Inhibits the Development of Diabetic Retinopathy indb/dbMice" @default.
• W1637778269 cites W151590161 @default.
• W1637778269 cites W1965341572 @default.
• W1637778269 cites W1974114036 @default.
• W1637778269 cites W1977829186 @default.
• W1637778269 cites W1995021046 @default.
• W1637778269 cites W1999870750 @default.
• W1637778269 cites W2005767645 @default.
• W1637778269 cites W2040310510 @default.
• W1637778269 cites W2041485080 @default.
• W1637778269 cites W2044878466 @default.
• W1637778269 cites W2047640394 @default.
• W1637778269 cites W2061735269 @default.
• W1637778269 cites W2062230299 @default.
• W1637778269 cites W2074154524 @default.
• W1637778269 cites W2078594613 @default.
• W1637778269 cites W2083207610 @default.
• W1637778269 cites W2089057070 @default.
• W1637778269 cites W2092579092 @default.
• W1637778269 cites W2093313526 @default.
• W1637778269 cites W2120276758 @default.
• W1637778269 cites W2138480916 @default.
• W1637778269 cites W2168261002 @default.
• W1637778269 cites W2171651020 @default.
• W1637778269 cites W2315244655 @default.
• W1637778269 cites W2471605942 @default.
• W1637778269 cites W4210953420 @default.
• W1637778269 cites W4211205882 @default.
• W1637778269 cites W4243282970 @default.
• W1637778269 cites W4244017022 @default.
• W1637778269 cites W4248904215 @default.
• W1637778269 cites W4254778823 @default.
• W1637778269 doi "https://doi.org/10.1155/2015/242517" @default.
• W1637778269 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4363582" @default.
• W1637778269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25821481" @default.
• W1637778269 hasPublicationYear "2015" @default.
• W1637778269 type Work @default.
• W1637778269 sameAs 1637778269 @default.
• W1637778269 citedByCount "8" @default.
• W1637778269 countsByYear W16377782692015 @default.
• W1637778269 countsByYear W16377782692016 @default.
• W1637778269 countsByYear W16377782692017 @default.
• W1637778269 countsByYear W16377782692018 @default.
• W1637778269 countsByYear W16377782692019 @default.
• W1637778269 countsByYear W16377782692020 @default.
• W1637778269 crossrefType "journal-article" @default.
• W1637778269 hasAuthorship W1637778269A5005205790 @default.
• W1637778269 hasAuthorship W1637778269A5013125144 @default.
• W1637778269 hasAuthorship W1637778269A5018938895 @default.
• W1637778269 hasAuthorship W1637778269A5028875731 @default.
• W1637778269 hasAuthorship W1637778269A5038840176 @default.
• W1637778269 hasAuthorship W1637778269A5039020375 @default.
• W1637778269 hasAuthorship W1637778269A5044788727 @default.
• W1637778269 hasAuthorship W1637778269A5059838901 @default.
• W1637778269 hasAuthorship W1637778269A5060454242 @default.
• W1637778269 hasAuthorship W1637778269A5079730676 @default.
• W1637778269 hasBestOaLocation W16377782691 @default.
• W1637778269 hasConcept C118487528 @default.
• W1637778269 hasConcept C126322002 @default.
• W1637778269 hasConcept C134018914 @default.
• W1637778269 hasConcept C185592680 @default.
• W1637778269 hasConcept C2778313320 @default.
• W1637778269 hasConcept C2779829184 @default.
• W1637778269 hasConcept C2780827179 @default.
• W1637778269 hasConcept C555293320 @default.
• W1637778269 hasConcept C71924100 @default.
• W1637778269 hasConceptScore W1637778269C118487528 @default.
• W1637778269 hasConceptScore W1637778269C126322002 @default.
• W1637778269 hasConceptScore W1637778269C134018914 @default.
• W1637778269 hasConceptScore W1637778269C185592680 @default.
• W1637778269 hasConceptScore W1637778269C2778313320 @default.
• W1637778269 hasConceptScore W1637778269C2779829184 @default.
• W1637778269 hasConceptScore W1637778269C2780827179 @default.
• W1637778269 hasConceptScore W1637778269C555293320 @default.
• W1637778269 hasConceptScore W1637778269C71924100 @default.
• W1637778269 hasFunder F4320321001 @default.
• W1637778269 hasLocation W16377782691 @default.
• W1637778269 hasLocation W16377782692 @default.
• W1637778269 hasLocation W16377782693 @default.
• W1637778269 hasLocation W16377782694 @default.
• W1637778269 hasOpenAccess W1637778269 @default.
• W1637778269 hasPrimaryLocation W16377782691 @default.
• W1637778269 hasRelatedWork W1985531100 @default.
• W1637778269 hasRelatedWork W2070371764 @default.

• next