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• W1637895087 abstract "Publisher Summary This chapter outlines the experiments that were instrumental in the identification of sarcolemmal proteins. It also focuses on the role of the proteins in the regulation of long-chain fatty acids (FA) utilization by major physiological stimuli, and the evidence for their altered functioning in type-1 and type-2 diabetes. A better understanding of the molecular mechanism by which these proteins act could help to design therapeutic strategies to help fight both forms of diabetes. FA is important substrates for skeletal muscle metabolic energy production. By virtue of its mass and its highly variable metabolic rate, skeletal muscle is a key player in the regulation of lipid homeostasis. The relative contribution of FA to metabolic energy production differs among the various muscle fiber types. Notably, FA utilization is relatively low in fast-twitch (type II) fibers, whereas slow-twitch oxidative (type I) fibers display considerably greater FA fluxes. Although FA presents an important oxidizable fuel, especially in type I fibers, oxidation is not their only destination. The non-oxidized portion of FA is incorporated into distinct cellular lipid fractions. Thus skeletal muscle possesses neutral lipid stores from which FA can be liberated to fulfill the metabolic demands during prolonged submaximal exercise. The driving force of FA to be taken up by skeletal muscle from the blood circulation is the concentration gradient between vascular space and the intracellular compartment of the myocyte. The chapter also explains uptake into skeletal muscle of type-1 and type-2 diabetic rat models." @default.
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• W1637895087 date "2003-01-01" @default.
• W1637895087 modified "2023-09-27" @default.
• W1637895087 title "Alterations in muscular fatty acid handling in diabetes" @default.
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• W1637895087 doi "https://doi.org/10.1016/s1569-2558(03)33012-7" @default.
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