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- W163802508 abstract "Background: Pain is an essential component of the alarm response to tissue injury. We hypothesised that neuropeptides substance P (SP) and Calcitonin Gene-Releated Peptide (CGRP), released from nociceptive fibres, contribute to progenitor cells (PC) mobilization in ischemia. Methods and Results: By immunostaining, we confirmed the expression of SP and CGRP within vesicles of fibre-like structures in mouse bone marrow (BM). Moreover, we found that NK1 and CLR/RAMP-1 (SP and CGRP receptors) were expressed on cells of the osteoblastic and vascular niches and co-expressed in PC with ckit, Sca-1 and Flk1. In in vitro migration assays, SP and CGRP attracted BM PC (SP, 1 nM: 1.8±0.2 fold; CGRP, 1 nM: 1.9±0.3 fold increase in migration; p=0.04 for both comparisons vs. control; N=3). Mouse dorsal root ganglia neurons (mDRGN) or their conditioned medium (CM) had similar promigratory effects (mDRGN: 2.1±0.2 fold, p pos /Flk1 pos PC fraction showed higher level of RAMP-1 (1.37 fold, p=0.05) and NK1 (1.11 fold, p=0.08) after ischemia. RAMP-1 and NK1 expression also increased in peripheral blood (PB) cKit pos /Flk1 pos PC (1.21 and 1.24 fold). Furthermore, we found that NK1 and CLR/RAMP-1 were expressed in human PB PC and that acute myocardial infarction (aMI) and chronic angina (CA) increased CD34 pos /KDR pos PC co-expressing RAMP-1 (control 0.004±0.001% of total mononuclear cells; aMI 0.008±0.001%, p pos /KDR pos PC fraction (RAMP-1: control 9.2±0.6%; aMI 15.5±1.8%, p Conclusion: Our results suggest that neurogenic mechanisms regulate PC mobilization in ischemia. Nociceptive signalling might represent a novel target for modulation of BM-mediated reparative response." @default.
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- W163802508 date "2010-11-23" @default.
- W163802508 modified "2023-09-26" @default.
- W163802508 title "Abstract 17004: Nociceptive Signalling Contributes to Progenitor Cells Activation and Mobilization in Ischemia" @default.
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