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- W1638366904 abstract "The humoral response of mice to an H-2 public specificity, termed H-2. '28' was found to be under genetic control. The genes determining this specificity were mapped to both the H-2K and H-2D regions, suggesting possible structural homologies between the products determined by these two regions. Genetic analyses indicated that a single non-H-2-linked gene regulates the anti-H-2. '28' response. In a backcross study, no linkage was detected between this putative H-2. '28' Ir gene and either the V H region or the Ly-2 locus to which the K-light chain locus is linked. Thus, a regulatory rather than a structural genetic locus seems a more likely basis for differences in response to this antigen. Our data further indicate that control of the humoral response to H-2. '28' is determinant specific since responses of the same backcross mice to other K and D alloantigens were not found to be subject to the same control." @default.
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- W1638366904 date "1977-04-01" @default.
- W1638366904 modified "2023-10-14" @default.
- W1638366904 title "Genetic Control of the Humoral Response to an H-2 Public Specificity" @default.
- W1638366904 doi "https://doi.org/10.4049/jimmunol.118.4.1403" @default.
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