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• W163847483 startingPage "427" @default.
• W163847483 abstract "The discovery and development of a new drug is a costly and uncertain undertaking, made even more so by stricter regulatory requirements on efficacy and toxicity. In the early stages of a drug discovery program, particularly in a new therapeutic area, it is quite often the case that compounds exhibiting high activity in an in vitro screen are found to be inactive in subsequent in vivo studies. The reasons for the lack of effect in vivo are often complex and can include any combination of factors such as, poor absorption from the site of administration, metabolism to an inactive form, inability to penetrate to the required receptor sites in vivo, or the choice of an inappropriate animal model. Even when an active compound is found, it may be difficult to determine at an early stage, whether the observed biological activity is due to the parent compound, an active metabolite or both. Whilst some information on plasma concentrations of the parent compound may be obtained using specific chromatographic assays, or some type of bioassay, comprehensive answers to the problems posed above would clearly benefit from a more complete metabolic profile for the compound(s) under investigation. Obtaining this type of information by conventional means, usually requires the production of the candidate drug in a radiolabeled form." @default.
• W163847483 created "2016-06-24" @default.
• W163847483 creator A5033654536 @default.
• W163847483 creator A5061761689 @default.
• W163847483 date "1987-01-01" @default.
• W163847483 modified "2023-09-23" @default.
• W163847483 title "High resolution nuclear magnetic resonance spectroscopy of biological samples as an aid to drug development" @default.
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• W163847483 doi "https://doi.org/10.1007/978-3-0348-9289-6_13" @default.
• W163847483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3326036" @default.
• W163847483 hasPublicationYear "1987" @default.
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