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• W1638808512 abstract "Abstract Background Hemorrhagic cystitis ( HC ) is a common complication after hematopoietic allogeneic stem cell transplantation ( HSCT ) associated with intensity of the conditioning regimen, cyclophosphamide (Cy) therapy, and BK polyomavirus ( BKP yV) infection. Methods We analyzed 33 consecutive haploidentical (haplo) HSCT recipients transplanted for hematologic diseases. Eleven patients had a previous transplant. Median follow‐up was 11 months. Graft‐versus‐host disease ( GVHD ) prophylaxis consisted of cyclosporine + mycophenolate mofetil and post‐ HSCT Cy. Results Thirty‐two of 33 patients achieved neutrophil recovery. Cumulative incidence ( CI ) of platelet recovery was 65%. CI grade II – IV acute GVHD was 44%. Twenty patients developed HC in a median time of 38 days. CI of HC at day 180 was 62%. BKP yV was positive in blood and urine of 91% of patients at HC onset. HC resolved in 18/20 patients. Factors associated with HC were previous transplant ( P = 0.01) and occurrence of cytomegalovirus reactivation before HC ( P = 0.05). Grade II – IV acute GVHD was not associated with HC ( P = 0.62). CI of day 180 viral infections was 73%. Two‐year overall survival (OS) was 50%; HC did not impact OS ( P = 0.29). Conclusion The incidence of HC after haplo with post‐ HSCT Cy is high and is associated with morbidity, especially in high‐risk patients such as those with a previous transplant history and with impaired immune reconstitution." @default.
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• W1638808512 date "2015-11-25" @default.
• W1638808512 modified "2023-10-17" @default.
• W1638808512 title "Incidence and risk factors for hemorrhagic cystitis in unmanipulated haploidentical transplant recipients" @default.
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• W1638808512 doi "https://doi.org/10.1111/tid.12455" @default.
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