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- W1638854533 abstract "Objective: To study the association between HHV-6 viruses and hippocampal volumes in patients with mesial temporal sclerosis (MTS).Background: Human herpes virus 6 (HHV-6) may play an etiologic role in mesial temporal lobe epilepsy and MTS. Previous studies found an association with febrile status epilepticus. We have reported higher prevalence of HHV-6 in MTS compared to other epilepsy etiologies.Design/Methods: We studied prospectively 34 patients referred to the Clinical Epilepsy Section, NINDS, NIH for evaluation of intractable epilepsy, with ictal video-EEG monitoring, 1.5-T or 3T GE Signa MRI with FLAIR, T1- and T2- weighted images, and 3-D SPGR or MP-RAGE. An investigator blinded to other data manually traced hippocampi manually on each slice, before assembly into three- dimensional volumes. The main study outcome measure was the hippocampal volume asymmetry index (AI) ipsilateral and contralateral to the seizure focus compared between HHV-6 positive and negative patients. Viral DNA was isolated from fresh brain tissue. For 25 patients, viral detection was performed using quantitative real time PCR specific for HHV-6A and HHV-6B. For nine patients, viral DNA detection was performed using digital droplet PCR (DdPCR) specific for HHV-6A and HHV-6B. DdPCR is a highly sensitive and precise novel PCR technology that enables absolute quantification of target DNA molecules. Statistical analysis was performed with SPSS.Results: HHV-6B was detected in 16 of 25 patients studied with real time PCR. Among 9 studied with DdPCR, one had HHV-6A, two HHV-6B, and two both viruses. HHV-6-negative patients had significantly greater AI and lower ipsilateral volume than HHV-6 positive patients (p<0.001). On ANOVA including epilepsy duration, HHV-6 status retained a significant effect on AI (p<0.01).Conclusion: Our data suggest multiple potential etiologies for MTS. HHV6 may have a protective effect on hippocampal volume.Study Supported By: Division of Intramural Research NINDS NIH Disclosure: Dr. Theodore has received personal compensation in an editorial capacity for Epilepsy Research. Dr. Theodore holds stock and/or stock options in General Electric. Dr. Leibovitch has nothing to disclose. Dr. Billioux has nothing to disclose. Dr. Germayen has nothing to disclose. Dr. Kalikhman has nothing to disclose. Dr. Inati has nothing to disclose. Dr. Heiss has nothing to disclose. Dr. Zaghloul has nothing to disclose. Dr. Jacobson has nothing to disclose." @default.
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- W1638854533 date "2014-04-08" @default.
- W1638854533 modified "2023-10-11" @default.
- W1638854533 title "Association Between Human Herpes Virus 6 And Hippocampal Volume In Mesial Temporal Lobe Epilepsy (I1-2.003)" @default.
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