Matches in SemOpenAlex for { <https://semopenalex.org/work/W1639005451> ?p ?o ?g. }
- W1639005451 endingPage "16754" @default.
- W1639005451 startingPage "16751" @default.
- W1639005451 abstract "Agents that mobilize sequestered intracellular Ca2+, including ionophore A23187, EGTA, thapsigargin, and Cbz-Gly-Phe-NH2 (where Cbz is benzyloxycarbonyl), or mild reducing agents, such as dithiothreitol, disrupt early protein processing in the endoplasmic reticulum (ER), inhibit translational initiation, and trigger the induction of GRP78, an ER resident protein. Inhibition of translational initiation in response to acute treatment (15-30 min) of intact GH3 pituitary cells with each of these agents was accompanied by an average 5-fold increase in the amount of phosphorylated eukaryotic initiation factor (eIF) 2 alpha and a 50% reduction in eIF-2B activity. With continued exposure to A23187 (3 h) rates of amino acid incorporation partially recovered, eIF-2 alpha became dephosphorylated, and the inhibition of eIF-2B activity was abolished. These chronic effects were blocked by actinomycin D. Accumulating evidence that the ER may regulate rates of translational initiation through a signaling system altering the activity of eIF-2 is discussed." @default.
- W1639005451 created "2016-06-24" @default.
- W1639005451 creator A5032886667 @default.
- W1639005451 creator A5038619133 @default.
- W1639005451 creator A5065556571 @default.
- W1639005451 creator A5068238911 @default.
- W1639005451 date "1992-10-01" @default.
- W1639005451 modified "2023-10-16" @default.
- W1639005451 title "Phosphorylation of eukaryotic initiation factor (eIF) 2 alpha and inhibition of eIF-2B in GH3 pituitary cells by perturbants of early protein processing that induce GRP78." @default.
- W1639005451 cites W1488906799 @default.
- W1639005451 cites W1493558178 @default.
- W1639005451 cites W1503965672 @default.
- W1639005451 cites W1520847252 @default.
- W1639005451 cites W1527202545 @default.
- W1639005451 cites W1529554110 @default.
- W1639005451 cites W1535214827 @default.
- W1639005451 cites W1535827761 @default.
- W1639005451 cites W1549162615 @default.
- W1639005451 cites W1550420936 @default.
- W1639005451 cites W1563280839 @default.
- W1639005451 cites W1575986179 @default.
- W1639005451 cites W1576136913 @default.
- W1639005451 cites W1583656960 @default.
- W1639005451 cites W1598963691 @default.
- W1639005451 cites W1599991866 @default.
- W1639005451 cites W1605456662 @default.
- W1639005451 cites W174722010 @default.
- W1639005451 cites W1853822177 @default.
- W1639005451 cites W1963909878 @default.
- W1639005451 cites W1964229393 @default.
- W1639005451 cites W1965177762 @default.
- W1639005451 cites W1968481412 @default.
- W1639005451 cites W1980669547 @default.
- W1639005451 cites W2037044371 @default.
- W1639005451 cites W2044787178 @default.
- W1639005451 cites W2051793369 @default.
- W1639005451 cites W2082376228 @default.
- W1639005451 cites W2089424335 @default.
- W1639005451 cites W2094857855 @default.
- W1639005451 cites W2111538369 @default.
- W1639005451 cites W2175307231 @default.
- W1639005451 cites W2340998542 @default.
- W1639005451 cites W2465001371 @default.
- W1639005451 doi "https://doi.org/10.1016/s0021-9258(18)41842-x" @default.
- W1639005451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1512215" @default.
- W1639005451 hasPublicationYear "1992" @default.
- W1639005451 type Work @default.
- W1639005451 sameAs 1639005451 @default.
- W1639005451 citedByCount "119" @default.
- W1639005451 countsByYear W16390054512012 @default.
- W1639005451 countsByYear W16390054512013 @default.
- W1639005451 countsByYear W16390054512014 @default.
- W1639005451 countsByYear W16390054512015 @default.
- W1639005451 countsByYear W16390054512016 @default.
- W1639005451 countsByYear W16390054512018 @default.
- W1639005451 countsByYear W16390054512019 @default.
- W1639005451 countsByYear W16390054512020 @default.
- W1639005451 countsByYear W16390054512021 @default.
- W1639005451 countsByYear W16390054512022 @default.
- W1639005451 countsByYear W16390054512023 @default.
- W1639005451 crossrefType "journal-article" @default.
- W1639005451 hasAuthorship W1639005451A5032886667 @default.
- W1639005451 hasAuthorship W1639005451A5038619133 @default.
- W1639005451 hasAuthorship W1639005451A5065556571 @default.
- W1639005451 hasAuthorship W1639005451A5068238911 @default.
- W1639005451 hasBestOaLocation W16390054511 @default.
- W1639005451 hasConcept C11960822 @default.
- W1639005451 hasConcept C126322002 @default.
- W1639005451 hasConcept C134018914 @default.
- W1639005451 hasConcept C159110408 @default.
- W1639005451 hasConcept C185592680 @default.
- W1639005451 hasConcept C2775944032 @default.
- W1639005451 hasConcept C49453240 @default.
- W1639005451 hasConcept C64943373 @default.
- W1639005451 hasConcept C71924100 @default.
- W1639005451 hasConcept C86803240 @default.
- W1639005451 hasConcept C95444343 @default.
- W1639005451 hasConceptScore W1639005451C11960822 @default.
- W1639005451 hasConceptScore W1639005451C126322002 @default.
- W1639005451 hasConceptScore W1639005451C134018914 @default.
- W1639005451 hasConceptScore W1639005451C159110408 @default.
- W1639005451 hasConceptScore W1639005451C185592680 @default.
- W1639005451 hasConceptScore W1639005451C2775944032 @default.
- W1639005451 hasConceptScore W1639005451C49453240 @default.
- W1639005451 hasConceptScore W1639005451C64943373 @default.
- W1639005451 hasConceptScore W1639005451C71924100 @default.
- W1639005451 hasConceptScore W1639005451C86803240 @default.
- W1639005451 hasConceptScore W1639005451C95444343 @default.
- W1639005451 hasIssue "24" @default.
- W1639005451 hasLocation W16390054511 @default.
- W1639005451 hasOpenAccess W1639005451 @default.
- W1639005451 hasPrimaryLocation W16390054511 @default.
- W1639005451 hasRelatedWork W1835699834 @default.
- W1639005451 hasRelatedWork W1966504330 @default.
- W1639005451 hasRelatedWork W1966775726 @default.
- W1639005451 hasRelatedWork W1979139803 @default.
- W1639005451 hasRelatedWork W2030889776 @default.
- W1639005451 hasRelatedWork W2037631372 @default.