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- W1639013603 abstract "Abstract Cecropin D was synthesized by solid-phase methods and shown to be homogeneous and of correct composition and molecular weight. It was indistinguishable from natural cecropin D and constitutes a structure proof for this peptide. Several analogs of cecropin D were synthesized and used to draw conclusions about the structural features contributing to antibacterial activity. They included [Lys1]cecropin D, [Gln3, Leu4] cecropin D, and cecropin D-(9-37). It was concluded that a strongly basic NH2-terminal segment is a prerequisite for antibacterial activity. A hybrid analog cecropin A-(1-11) D-(12-37) was designed and predicted to have enhanced potency. It was found to be 5 to 55 times as active as cecropin D against six of the bacteria tested and was slightly more active than cecropin A. However, against Bacillus subtilis Bs11 the analog was 6 times more active than cecropin A." @default.
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- W1639013603 date "1989-04-01" @default.
- W1639013603 modified "2023-10-12" @default.
- W1639013603 title "The Chemical Synthesis of Cecropin D and an Analog with Enhanced Antibacterial Activity" @default.
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- W1639013603 doi "https://doi.org/10.1016/s0021-9258(18)83342-7" @default.
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