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- W1639110634 abstract "Hepatocyte growth factor (HGF) regulates satellite cell activation, proliferation, and differentiation. We analyzed the dose-dependent effects of HGF on myogenesis. Murine C2C12 and human donor-derived skeletal muscle myoblasts were treated with 0, 2, or 10 ng/ml HGF followed by assessment of proliferation and differentiation. HGF (2 ng/ml) significantly promoted cell division, but reduced myogenic commitment and fusion. Conversely, 10 ng/ml HGF reduced proliferative capability, but increased differentiation. c-Met expression analysis revealed significantly decreased expression in differentiating cells cultured with 2 ng/ml HGF, but increased expression in proliferating cells with 10 ng/ml HGF. Mitogen-activated protein kinase (MAPKs: ERK, JNK, or p38K) and phosphatidylinositol-3-kinase (PI3K) inhibition abrogated the HGF-stimulated increase in cell number. Interestingly, PI3K and p38 kinase facilitated the negative effect of HGF on proliferation, while ERK inhibition abrogated the HGF-mediated decrease in differentiation. Dose-dependent effects of HGF are mediated by changes in c-Met expression and downstream MAPK and PI3K signalling." @default.
- W1639110634 created "2016-06-24" @default.
- W1639110634 creator A5005993498 @default.
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- W1639110634 creator A5030819894 @default.
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- W1639110634 date "2015-05-04" @default.
- W1639110634 modified "2023-10-06" @default.
- W1639110634 title "Dose-dependent modulation of myogenesis by HGF: implications for c-Met expression and downstream signalling pathways" @default.
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- W1639110634 doi "https://doi.org/10.3109/08977194.2015.1058260" @default.
- W1639110634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26135603" @default.
- W1639110634 hasPublicationYear "2015" @default.
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