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- W1639403002 startingPage "45" @default.
- W1639403002 abstract "Interest in the structural proteins of neurons has increased in past years as a result of the convergence of three lines of investigation. First, with improved methods of fixation, microtubules and neurofilaments have been described as constant components of nerve cells and thus neuronal organelles. Such recognition has led to their isolation and partial chemical characterization. Second, both microtubules and neurofilaments have been implicated in the nonrandom movement of substances within the cytoplasm, a process termed “axoplasmic flow.” Now it is clear that this directed circulation of cytoplasm occurs not only in axons but also in the cell body and dendrites. Third, disorders of these proteins lead to the pathological condition known as “neurofibrillary degeneration,” which occurs in aging. This chapter considers the normal distribution, configuration, structure, and the composition of microtubules and neurofilaments and the relation between their distribution, function, and pathology. The identification of these images as axons, dendrites, cell bodies, or synapses depends on the distribution of organelles in the structure. Practically, the microscopist learns to identify profiles from their overall size and shape. Thus, a dendrite is usually larger than its neighboring, unmyelinated axon." @default.
- W1639403002 created "2016-06-24" @default.
- W1639403002 creator A5016265261 @default.
- W1639403002 creator A5088768347 @default.
- W1639403002 date "1972-01-01" @default.
- W1639403002 modified "2023-09-27" @default.
- W1639403002 title "Neuronal Microtubules, Neurofilaments, and Microfilaments" @default.
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