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- W1639441512 abstract "This chapter describes behavioral aberrations in methamphetamine-intoxicated animals and chemical correlates in the brain. It is known that behavioral changes of various duration can be produced by some kinds of drugs, which thus provide valuable tools for elucidating the mechanism of development of behavioral changes. At the beginning of the investigation, the blood level and the excretion into the urine of methamphetamine after the drug had been taken were determined in addicts and in normal volunteers. The tissue distribution of methamphetamine was also examined in acute and chronic experiments on guinea-pigs. The reduction in motor activity persisted long after the cessation of the drug injection, and it required about 10 weeks for complete recovery. This reduction in the motor activity cannot be ascribed to ataxia or exhaustion, since the mean running velocity, which was measured also by the wheel, remained almost unchanged throughout the course of the experiment. The ratio of night to daytime activity of the intoxicated mice was found to have decreased from the normal value of 4 to less than 1." @default.
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- W1639441512 date "1966-01-01" @default.
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- W1639441512 title "Behavioral Aberrations in Methamphetamine-intoxicated Animals and Chemical Correlates in the Brain" @default.
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- W1639441512 doi "https://doi.org/10.1016/s0079-6123(08)64231-4" @default.
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