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- W1639793329 abstract "Membrane transport is an essential step for the delivery of antifolate drugs to their intracellular targets. At least two structurally unrelated transport systems have been characterized for their role in the uptake of reduced folate cofactors and antifolate compounds; the reduced folate/methotrexate carrier (RF/MTX-carrier) (1) and a membrane-associated folate binding protein (mFBP) (reviewed in 2, 3, and 4). Recent studies have shown that both proteins can be expressed within the same cell (5).KeywordsFolate ReceptorThymidylate SynthetaseFolate TransportFolate Binding ProteinAntifolate DrugThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
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- W1639793329 date "1993-01-01" @default.
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- W1639793329 title "Identification of a Reduced Folate/Methotrexate Carrier in Human KB-Cells Expressing High Levels of Membrane Associated Folate Binding Protein" @default.
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- W1639793329 doi "https://doi.org/10.1007/978-1-4615-2960-6_161" @default.
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