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- W1639908700 abstract "Mathematical models of glucose, insulin and pancreatic beta-cell mass dynamics are essential to our understanding of the physiological basis of the development of type 2 diabetes. The classical view of diabetes is that the disease develops due to insulin insufficiency. An alternate viewpoint that has recently staged a revival is that diabetogenesis is a hypersecretion disorder. A prominent model of diabetes progression is the βIG model due to Topp and coworkers. Here we study two new variants of the Topp model, which we name Topp-IR and Topp-HS. Topp-IR is a model in which increasing insulin resistance is sufficient to drive a system away from health towards hyperglycemia. Topp-HS describes the hypersecretion model in mathematical terms. We thus show that the hypersecretion hypothesis is theoretically sound, and is therefore a potential route to diabetes. On the basis of insights derived from modeling, we clarify several subtleties of that argument, including postulating a central role for transient insulin peaks in driving insulin resistance." @default.
- W1639908700 created "2016-06-24" @default.
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- W1639908700 date "2015-11-01" @default.
- W1639908700 modified "2023-09-25" @default.
- W1639908700 title "Insulin resistance or hypersecretion? The βIG picture revisited" @default.
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- W1639908700 doi "https://doi.org/10.1016/j.jtbi.2015.07.033" @default.
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