Matches in SemOpenAlex for { <https://semopenalex.org/work/W164002144> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W164002144 endingPage "425" @default.
- W164002144 startingPage "417" @default.
- W164002144 abstract "1. Samples of normal skin from four patients, post-burn hypertrophic scar from five patients and post-burn mature scar from six patients were analysed for hydroxyproline, water and uronic acid and extracted with guanidinium chloride to yield the proteoglycan pool. A large chondroitin sulphate proteoglycan and biglycan were purified from one hypertrophic scar biopsy and decorin from a normal skin biopsy, by ion-exchange chromatography, gel-filtration and hydrophobic interaction chromatography. These purified proteoglycans were used in an inhibition ELISA assay to estimate the quantities of each in the tissue samples. 2. Samples of post-burn hypertrophic scar had on average 30% less hydroxyproline, 12% more water and 2.4 times as much uronic acid as normal skin. These differences were all statistically significant, whereas the small differences between mature scars and normal skin were not. The content of decorin in hypertrophic scars was only 25% of that in normal skin whereas the large chondroitin sulphate proteoglycan and biglycan were each about 6-fold higher. The mature scars had slightly elevated levels of large chondroitin sulphate proteoglycan and biglycan and a reduced content of decorin compared with normal skin but these differences were not statistically significant. 3. The results suggest that aberrant proteoglycan metabolism is a significant factor contributing to the altered physical properties of hypertrophic scars and that maturation of post-burn scars is dependent on a return of the relative proportions and concentrations of proteoglycans to those characteristic of normal dermis." @default.
- W164002144 created "2016-06-24" @default.
- W164002144 creator A5011013562 @default.
- W164002144 creator A5013380616 @default.
- W164002144 creator A5032667091 @default.
- W164002144 creator A5071847376 @default.
- W164002144 creator A5091693040 @default.
- W164002144 date "1996-05-01" @default.
- W164002144 modified "2023-10-16" @default.
- W164002144 title "Chemical Characterization and Quantification of Proteoglycans in Human Post-Burn Hypertrophic and Mature Scars" @default.
- W164002144 doi "https://doi.org/10.1042/cs0900417" @default.
- W164002144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8665780" @default.
- W164002144 hasPublicationYear "1996" @default.
- W164002144 type Work @default.
- W164002144 sameAs 164002144 @default.
- W164002144 citedByCount "99" @default.
- W164002144 countsByYear W1640021442012 @default.
- W164002144 countsByYear W1640021442015 @default.
- W164002144 countsByYear W1640021442016 @default.
- W164002144 countsByYear W1640021442017 @default.
- W164002144 countsByYear W1640021442018 @default.
- W164002144 countsByYear W1640021442019 @default.
- W164002144 countsByYear W1640021442020 @default.
- W164002144 countsByYear W1640021442021 @default.
- W164002144 countsByYear W1640021442022 @default.
- W164002144 countsByYear W1640021442023 @default.
- W164002144 crossrefType "journal-article" @default.
- W164002144 hasAuthorship W164002144A5011013562 @default.
- W164002144 hasAuthorship W164002144A5013380616 @default.
- W164002144 hasAuthorship W164002144A5032667091 @default.
- W164002144 hasAuthorship W164002144A5071847376 @default.
- W164002144 hasAuthorship W164002144A5091693040 @default.
- W164002144 hasConcept C142724271 @default.
- W164002144 hasConcept C153074725 @default.
- W164002144 hasConcept C185592680 @default.
- W164002144 hasConcept C189165786 @default.
- W164002144 hasConcept C2776016237 @default.
- W164002144 hasConcept C2776661909 @default.
- W164002144 hasConcept C2776735749 @default.
- W164002144 hasConcept C2778698245 @default.
- W164002144 hasConcept C2778916964 @default.
- W164002144 hasConcept C2779335624 @default.
- W164002144 hasConcept C2779553658 @default.
- W164002144 hasConcept C2779794767 @default.
- W164002144 hasConcept C2779797417 @default.
- W164002144 hasConcept C515207424 @default.
- W164002144 hasConcept C55493867 @default.
- W164002144 hasConcept C71924100 @default.
- W164002144 hasConceptScore W164002144C142724271 @default.
- W164002144 hasConceptScore W164002144C153074725 @default.
- W164002144 hasConceptScore W164002144C185592680 @default.
- W164002144 hasConceptScore W164002144C189165786 @default.
- W164002144 hasConceptScore W164002144C2776016237 @default.
- W164002144 hasConceptScore W164002144C2776661909 @default.
- W164002144 hasConceptScore W164002144C2776735749 @default.
- W164002144 hasConceptScore W164002144C2778698245 @default.
- W164002144 hasConceptScore W164002144C2778916964 @default.
- W164002144 hasConceptScore W164002144C2779335624 @default.
- W164002144 hasConceptScore W164002144C2779553658 @default.
- W164002144 hasConceptScore W164002144C2779794767 @default.
- W164002144 hasConceptScore W164002144C2779797417 @default.
- W164002144 hasConceptScore W164002144C515207424 @default.
- W164002144 hasConceptScore W164002144C55493867 @default.
- W164002144 hasConceptScore W164002144C71924100 @default.
- W164002144 hasIssue "5" @default.
- W164002144 hasLocation W1640021441 @default.
- W164002144 hasLocation W1640021442 @default.
- W164002144 hasOpenAccess W164002144 @default.
- W164002144 hasPrimaryLocation W1640021441 @default.
- W164002144 hasRelatedWork W1759662028 @default.
- W164002144 hasRelatedWork W1974303603 @default.
- W164002144 hasRelatedWork W1988047807 @default.
- W164002144 hasRelatedWork W1991388845 @default.
- W164002144 hasRelatedWork W2037042842 @default.
- W164002144 hasRelatedWork W2089612473 @default.
- W164002144 hasRelatedWork W2123503971 @default.
- W164002144 hasRelatedWork W2284692617 @default.
- W164002144 hasRelatedWork W2614685735 @default.
- W164002144 hasRelatedWork W2752273860 @default.
- W164002144 hasVolume "90" @default.
- W164002144 isParatext "false" @default.
- W164002144 isRetracted "false" @default.
- W164002144 magId "164002144" @default.
- W164002144 workType "article" @default.