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- W164027984 endingPage "350" @default.
- W164027984 startingPage "317" @default.
- W164027984 abstract "The catecholamines dopamine (DA) and norepinephrine (noradrenaline, NA) exert a strong modulatory control over the “motive circuit”. This neuronal circuit comprises cortical, striatal and thalamic areas and underlies the behavioural expression of motivated behaviour, including classical and operant conditioning. Conditioned and unconditioned stimuli with a strong motivational salience have rapid access to the catecholaminergic systems and activation by such stimuli may result in the modulation of a wide array of neuronal processes in the brain. Microdialysis is the universally applicable method to determine the transmitter efflux resulting from this activation. In this chapter, the evidence that DA and NA efflux is increased by conditioned approach and avoidance behaviour and during instrumental actions is reviewed and data obtained using microdialysis are compared with results from in vivo electrophysiological and electrochemical studies. Special attention is paid to the suggestions that the catecholamines support flexibility in operant responding and may have a unique role in reward-related learning." @default.
- W164027984 created "2016-06-24" @default.
- W164027984 creator A5017096014 @default.
- W164027984 date "2006-01-01" @default.
- W164027984 modified "2023-09-26" @default.
- W164027984 title "Chapter 4.2 Microdialysis of dopamine and norepinephrine during conditioning and operant behaviour" @default.
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