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• W1640389729 abstract "Children infected with HIV are one of the fastest increasing segments of the AIDS epidemic. Central Nervous System can be directly infected by HIV. Imaging studies have demonstrated abnormalities in the developing brains of HIVinfected children. Pediatric neuro-AIDS may be the first clinical manifestation of HIV infection in children born to HIV infected mothers. Neurodevelopmental and psychomotor problems may be the first presenting symptoms of AIDS. These symptoms may be an important determinant of therapeutic efficacy and may cause significant impairments in both the child’s overall functioning and quality of life. A prospective study of French children with congenital or prenatal HIV-1 infection reported a 19% rate of significant central nervous system impairment. The European Collaborative Study reported a 13% rate of serious neurological signs and symptoms in infected children and a much higher rate (31%) in children with Acquired Immunodeficiency Syndrome (AIDS) o AIDS-related complex. A multicenter epidemiologic study in the United States showed HIV-1 encephalopathy diagnosed in 23% of children with perinatally acquired AIDS. In Argentine, HIV-1 related encephalopathy and developmental impairment may appear early in the disease process, in 24% rate of children under 13 years of age. In some children, developmental impairment may appear early in the disease process, preceding other medical symptoms of infection, while in other children, this impairment occurs only after a period of normal development. Psychomotor and neurodevelopmental examination of infants born to HIV-infected women, may be useful for the prompt and reliable identification of infants at high risk of Central Nervous System disease progression, before the onset of encephalopathy. The aim of this study was to evaluate the effectiveness of the Scale of Psychomotor Development Examination (EEDP) of Rodriguez, Arancibia, and Undurraga (1978) and the Method for Neurologic Evaluation within the First Year of Life (AT) of Amiel Tison, and Grenier (1981), to detect and monitor early signs of abnormality in cognitive and motor Kufa, Somaruga, Zarlenga y Pollier INTERDISCIPLINARIA, 2003, 20,2, 173-203 175 development, associated to HIV encephalopathy, in infants born to HIV-infected women, during the first 24 months of age. The scales selected were administered to 35 infants born to HIinfected women, with a median follow-up of 24 months. A psychosocial questionnaire was administered to a sample of 90 mothers (who have 20 30 years old), in order to describe psychosocial factors associated to HIV/AIDS. The sample of 90 mothers was divided en two groups: a group of 35 HIV+ mothers (whose babys are the possible HIV infected babys of the sample), and a group of 55 seronegative healthy mothers, whose baby are healthy and born in term. The psychosocial questionnaire shows significative presence (Chi square test) of biopsychosocial risk in seropositive mothers and her partners. That was show by the presence of ilegal drug use, alcoholism, delinquency, promiscuousy, tatoo, etc. In concern to the scales we are studying, preliminary results showed more sensitivity of AT to detect neurodevelopmental problems than EEDP (specially in the 3rd , 6th, and 9th month of age), but low specificity; because all infants that obtained abnormal results do not result HIV infected. Only one acute severe HIV-related encephalopathy was identified among the 35 infants born to HIV-infected women. In the present study, the EEDP was not sensitive among infants born to HIV-infected women in the first year of life, but it was in the second year of life. The EEDP was found to detect psychomotor-developmental differences between HIVinfected and uninfected children al 15 and 24 months of age. In summary, the two test studied appears to be usefully tools to monitor neurodevelopment in infants born to HIVinfected women. AT would be a base screening. If this screening shows risk values, we should use a more complete mental test as EEDP." @default.
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• W1640389729 date "2003-01-01" @default.
• W1640389729 modified "2023-09-26" @default.
• W1640389729 title "Predicción precoz de encefalopatía por VIH-1 en niñosde 0 a 24 meses de edad" @default.
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