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• W1640397007 startingPage "63" @default.
• W1640397007 abstract "When animals are exposed to a stimulus that has no consequences they are subsequently impaired in learning that this stimulus predicts an important event, such as footshock. This retarding effect of stimulus pre-exposure is called latent inhibition (LI) and is reliably disrupted by amphetamine, antipsychotics having an opposite effect. The present experiments investigated whether agents which affect serotonergic transmission also attenuate LI, using a conditioned suppression of drinking procedure. The results showed that the 5-HT 2 antagonist ritanserin (2.0 mg/kg), and the 5-HT 1b agonist RU 24969 (0.5 and 10.0 mg/kg) attenuated LI by increasing learning in pre-exposed animals, whilst the effects of the 5-HT 1a agonist 8-OH-DPAT (0.38 mg/kg), though in a similar direction, were not significant. These experiments provide partial support for the involvement of serotonin in LI. Since amphetamine-induced attenuation of LI has been proposed as a model for the attentional deficits found in acute schizophrenia, these results are discussed in terms of the possible involvement of reduced serotonergic function in schizophrenic attentional disorder." @default.
• W1640397007 created "2016-06-24" @default.
• W1640397007 creator A5038369135 @default.
• W1640397007 creator A5054724206 @default.
• W1640397007 creator A5057849647 @default.
• W1640397007 date "1993-01-01" @default.
• W1640397007 modified "2023-09-28" @default.
• W1640397007 title "The effects of ritanserin, RU 24969 and 8-OH-DPAT on latent inhibition in the rat" @default.
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• W1640397007 doi "https://doi.org/10.1177/026988119300700110" @default.
• W1640397007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22290372" @default.
• W1640397007 hasPublicationYear "1993" @default.
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