Matches in SemOpenAlex for { <https://semopenalex.org/work/W1640512254> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W1640512254 endingPage "14841" @default.
- W1640512254 startingPage "14839" @default.
- W1640512254 abstract "Interleukin-8 (IL-8) is one of the most potent chemotactic agents for neutrophils and has been implicated as a major mediator of inflammation. The IL-8 receptor is expressed exclusively in neutrophils and belongs to the family of G-protein-coupled receptors. In a recent paper we reported the characterization of a cDNA clone, F3R, isolated from a neutrophil cDNA library and showed that it encodes a G-protein-coupled receptor which is exclusively expressed in neutrophils. We also suggested, based on expression studies in Xenopus oocytes, that the F3R protein product is an isoform of the (fMLP) receptor (Thomas, K. M., Pyun, H. Y., and Navarro, J. (1990) J. Biol. Chem. 265, 20061-20064). In this work, the F3R receptor cDNA is expressed in monkey kidney cells (COS-7) and is shown to encode the IL-8 receptor. F3R cDNA does not encode for a fMLP receptor isoform. We show conclusively that the F3R-transfected COS-7 cells express the IL-8 receptor at a density equivalent to that observed in neutrophils. The pharmacological profile of the F3R-transfected cells is the same as that of neutrophils. The apparent Kd values for binding of 125I-IL-8 to neutrophils and F3R-transfected COS-7 cell membranes were 1.2 and 1.4 nM, respectively. Antipeptide antibodies against a partial sequence of the F3R protein product specifically immunoprecipitate the IL-8 receptor from transfected cells as well as neutrophils. The molecular characterization of the IL-8 receptor should provide the basis for further studies on the identification of the binding domain of this inflammatory receptor." @default.
- W1640512254 created "2016-06-24" @default.
- W1640512254 creator A5023260898 @default.
- W1640512254 creator A5027078385 @default.
- W1640512254 creator A5088616559 @default.
- W1640512254 date "1991-08-01" @default.
- W1640512254 modified "2023-10-16" @default.
- W1640512254 title "The interleukin-8 receptor is encoded by a neutrophil-specific cDNA clone, F3R" @default.
- W1640512254 cites W1486569222 @default.
- W1640512254 cites W1808126443 @default.
- W1640512254 cites W1988298211 @default.
- W1640512254 cites W2010349134 @default.
- W1640512254 cites W2014651332 @default.
- W1640512254 cites W2041987085 @default.
- W1640512254 cites W2076892293 @default.
- W1640512254 cites W2077883691 @default.
- W1640512254 cites W2107662082 @default.
- W1640512254 cites W2147657681 @default.
- W1640512254 doi "https://doi.org/10.1016/s0021-9258(18)98547-9" @default.
- W1640512254 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1714446" @default.
- W1640512254 hasPublicationYear "1991" @default.
- W1640512254 type Work @default.
- W1640512254 sameAs 1640512254 @default.
- W1640512254 citedByCount "75" @default.
- W1640512254 countsByYear W16405122542013 @default.
- W1640512254 countsByYear W16405122542014 @default.
- W1640512254 countsByYear W16405122542015 @default.
- W1640512254 countsByYear W16405122542019 @default.
- W1640512254 crossrefType "journal-article" @default.
- W1640512254 hasAuthorship W1640512254A5023260898 @default.
- W1640512254 hasAuthorship W1640512254A5027078385 @default.
- W1640512254 hasAuthorship W1640512254A5088616559 @default.
- W1640512254 hasBestOaLocation W16405122541 @default.
- W1640512254 hasConcept C104317684 @default.
- W1640512254 hasConcept C116016267 @default.
- W1640512254 hasConcept C153911025 @default.
- W1640512254 hasConcept C170493617 @default.
- W1640512254 hasConcept C187882448 @default.
- W1640512254 hasConcept C203014093 @default.
- W1640512254 hasConcept C36069631 @default.
- W1640512254 hasConcept C54355233 @default.
- W1640512254 hasConcept C81089528 @default.
- W1640512254 hasConcept C86803240 @default.
- W1640512254 hasConceptScore W1640512254C104317684 @default.
- W1640512254 hasConceptScore W1640512254C116016267 @default.
- W1640512254 hasConceptScore W1640512254C153911025 @default.
- W1640512254 hasConceptScore W1640512254C170493617 @default.
- W1640512254 hasConceptScore W1640512254C187882448 @default.
- W1640512254 hasConceptScore W1640512254C203014093 @default.
- W1640512254 hasConceptScore W1640512254C36069631 @default.
- W1640512254 hasConceptScore W1640512254C54355233 @default.
- W1640512254 hasConceptScore W1640512254C81089528 @default.
- W1640512254 hasConceptScore W1640512254C86803240 @default.
- W1640512254 hasIssue "23" @default.
- W1640512254 hasLocation W16405122541 @default.
- W1640512254 hasOpenAccess W1640512254 @default.
- W1640512254 hasPrimaryLocation W16405122541 @default.
- W1640512254 hasRelatedWork W1985344842 @default.
- W1640512254 hasRelatedWork W2016601204 @default.
- W1640512254 hasRelatedWork W2017357718 @default.
- W1640512254 hasRelatedWork W2041939334 @default.
- W1640512254 hasRelatedWork W2055292695 @default.
- W1640512254 hasRelatedWork W2060783010 @default.
- W1640512254 hasRelatedWork W2112937092 @default.
- W1640512254 hasRelatedWork W2328623076 @default.
- W1640512254 hasRelatedWork W2401378784 @default.
- W1640512254 hasRelatedWork W3148645544 @default.
- W1640512254 hasVolume "266" @default.
- W1640512254 isParatext "false" @default.
- W1640512254 isRetracted "false" @default.
- W1640512254 magId "1640512254" @default.
- W1640512254 workType "article" @default.